The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host

ABSTRACT Cryptococcosis is the leading invasive fungal infection in the world today. Over the past century, the causative agents, Cryptococcus neoformans and Cryptococcus gattii, have risen from the status of medical curiosities to common but life-threatening central nervous system pathogens. In an...

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Autor principal:	John R. Perfect
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/1aee5f628f48481197bce2fce6f0a8e1
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spelling	oai:doaj.org-article:1aee5f628f48481197bce2fce6f0a8e12021-11-15T15:39:10ZThe Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host10.1128/mBio.00165-122150-7511https://doaj.org/article/1aee5f628f48481197bce2fce6f0a8e12012-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00165-12https://doaj.org/toc/2150-7511ABSTRACT Cryptococcosis is the leading invasive fungal infection in the world today. Over the past century, the causative agents, Cryptococcus neoformans and Cryptococcus gattii, have risen from the status of medical curiosities to common but life-threatening central nervous system pathogens. In an elegant experimental pathobiology study of these two organisms carried out by Ngamskulrungroj et al., there are three matters that merit further discussion. First is the question of whether there is a variable specific pathobiology for each yeast strain. Does it make biological and clinical sense to designate C. neoformans and C. gattii as two separate species? Second is the matter of how the organisms differ pathologically at the site of infection. Finally, there is the possibility that the human immune system responds differently to each species. Although no single study can provide definitive mechanistic answers to the important questions, this experimental pathology study and its discussion clearly frame the issues to be dissected.John R. PerfectAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 4 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 John R. Perfect The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host
description	ABSTRACT Cryptococcosis is the leading invasive fungal infection in the world today. Over the past century, the causative agents, Cryptococcus neoformans and Cryptococcus gattii, have risen from the status of medical curiosities to common but life-threatening central nervous system pathogens. In an elegant experimental pathobiology study of these two organisms carried out by Ngamskulrungroj et al., there are three matters that merit further discussion. First is the question of whether there is a variable specific pathobiology for each yeast strain. Does it make biological and clinical sense to designate C. neoformans and C. gattii as two separate species? Second is the matter of how the organisms differ pathologically at the site of infection. Finally, there is the possibility that the human immune system responds differently to each species. Although no single study can provide definitive mechanistic answers to the important questions, this experimental pathology study and its discussion clearly frame the issues to be dissected.
format	article
author	John R. Perfect
author_facet	John R. Perfect
author_sort	John R. Perfect
title	The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host
title_short	The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host
title_full	The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host
title_fullStr	The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host
title_full_unstemmed	The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host
title_sort	triple threat of cryptococcosis: it’s the body site, the strain, and/or the host
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/1aee5f628f48481197bce2fce6f0a8e1
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The Triple Threat of Cryptococcosis: It’s the Body Site, the Strain, and/or the Host

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