Coenzyme Q10 effects in neurodegenerative disease
Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,21Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement i...
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Dove Medical Press
2009
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oai:doaj.org-article:1af4ca5fd8ab49b58681c1b6bd15f3cf2021-12-02T00:17:02ZCoenzyme Q10 effects in neurodegenerative disease1176-63281178-2021https://doaj.org/article/1af4ca5fd8ab49b58681c1b6bd15f3cf2009-11-01T00:00:00Zhttp://www.dovepress.com/coenzyme-q10-effects-in-neurodegenerative-disease-a3707https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,21Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease. Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress. Studies of in vitro models of neuronal toxicity and animal models of neurodegenerative disorders have demonstrated potential neuroprotective effects of CoQ10. With this data in mind, several clinical trials of CoQ10 have been performed in Parkinson’s disease and atypical Parkinson’s syndromes, Huntington’s disease, Alzheimer disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis, with equivocal findings. CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy. Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ10 in neurodegenerative diseases.Keywords: coenzyme Q10, neurodegenerative disease, Parkinson’s disease, Huntington’s disease, mitochondrial dysfunction Meredith SpindlerM Flint BealClaire HenchcliffeDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2009, Iss default, Pp 597-610 (2009) |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Meredith Spindler M Flint Beal Claire Henchcliffe Coenzyme Q10 effects in neurodegenerative disease |
| description |
Meredith Spindler1, M Flint Beal1,2, Claire Henchcliffe1,21Department of Neurology, 2Department of Neuroscience, Weill Medical College of Cornell University, New York, NY, USAAbstract: Coenzyme Q10 (CoQ10) is an essential cofactor in the mitochondrial respiratory chain, and as a dietary supplement it has recently gained attention for its potential role in the treatment of neurodegenerative disease. Evidence for mitochondrial dysfunction in neurodegenerative disorders derives from animal models, studies of mitochondria from patients, identification of genetic defects in patients with neurodegenerative disease, and measurements of markers of oxidative stress. Studies of in vitro models of neuronal toxicity and animal models of neurodegenerative disorders have demonstrated potential neuroprotective effects of CoQ10. With this data in mind, several clinical trials of CoQ10 have been performed in Parkinson’s disease and atypical Parkinson’s syndromes, Huntington’s disease, Alzheimer disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis, with equivocal findings. CoQ10 is widely available in multiple formulations and is very well tolerated with minimal adverse effects, making it an attractive potential therapy. Phase III trials of high-dose CoQ10 in large sample sizes are needed to further ascertain the effects of CoQ10 in neurodegenerative diseases.Keywords: coenzyme Q10, neurodegenerative disease, Parkinson’s disease, Huntington’s disease, mitochondrial dysfunction |
| format |
article |
| author |
Meredith Spindler M Flint Beal Claire Henchcliffe |
| author_facet |
Meredith Spindler M Flint Beal Claire Henchcliffe |
| author_sort |
Meredith Spindler |
| title |
Coenzyme Q10 effects in neurodegenerative disease |
| title_short |
Coenzyme Q10 effects in neurodegenerative disease |
| title_full |
Coenzyme Q10 effects in neurodegenerative disease |
| title_fullStr |
Coenzyme Q10 effects in neurodegenerative disease |
| title_full_unstemmed |
Coenzyme Q10 effects in neurodegenerative disease |
| title_sort |
coenzyme q10 effects in neurodegenerative disease |
| publisher |
Dove Medical Press |
| publishDate |
2009 |
| url |
https://doaj.org/article/1af4ca5fd8ab49b58681c1b6bd15f3cf |
| work_keys_str_mv |
AT meredithspindler coenzymeq10effectsinneurodegenerativedisease AT mflintbeal coenzymeq10effectsinneurodegenerativedisease AT clairehenchcliffe coenzymeq10effectsinneurodegenerativedisease |
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1718403786584621056 |