Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs

Abstract To evaluate changes in inner retinal layer (IRL) thicknesses in patients with type 1 diabetes mellitus (DM1) with no diabetic retinopathy (DR) using two different optical coherence tomography (OCT) devices. Ninety DM1 and 60 healthy eyes were evaluated using spectral domain (SD)-OCT and swe...

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Autores principales:	Elvira Orduna-Hospital, Ana Sanchez-Cano, Lorena Perdices, Javier Acha, Elena María Lopez-Alaminos, Isabel Pinilla
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1af643e3d3a941d2ac98a1b87a775ef6
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spelling	oai:doaj.org-article:1af643e3d3a941d2ac98a1b87a775ef62021-12-02T15:52:25ZChanges in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs10.1038/s41598-021-89992-w2045-2322https://doaj.org/article/1af643e3d3a941d2ac98a1b87a775ef62021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89992-whttps://doaj.org/toc/2045-2322Abstract To evaluate changes in inner retinal layer (IRL) thicknesses in patients with type 1 diabetes mellitus (DM1) with no diabetic retinopathy (DR) using two different optical coherence tomography (OCT) devices. Ninety DM1 and 60 healthy eyes were evaluated using spectral domain (SD)-OCT and swept source (SS)-OCT to measure changes in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and inner nuclear layer (INL) thicknesses in all Early Treatment of Diabetic Retinopathy Study (ETDRS) macular areas. Functional tests were performed in both groups, including ETDRS with 100, 2.5 and 1.25% contrast, and color vision. The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control groups, respectively. Visual acuity (VA) with ETDRS 1.25% was lower in the DM1 patients. Both ETDRS 2.5% and color vision were lower in the DM1 group but did not reach statistical significance. Retinal thicknesses in the central area and in the vertical outer areas were higher in the DM1 group. Differences were found in the IRL with no changes in the outer ones. Long-term DM1 patients with no DR maintained visual function, with a decrease in VA with 1.25% ETDRS contrast. Macular thickness measurements were higher using Spectralis SD-OCT than DRI Triton SS-OCT, and DM1 patients had a decrease in IRL thickness, especially in the GCL at the parafoveal level, generating thinning of the RNFL in the peripheral areas. There were no differences in outer retinal layer (ORL) thickness.Elvira Orduna-HospitalAna Sanchez-CanoLorena PerdicesJavier AchaElena María Lopez-AlaminosIsabel PinillaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elvira Orduna-Hospital Ana Sanchez-Cano Lorena Perdices Javier Acha Elena María Lopez-Alaminos Isabel Pinilla Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs
description	Abstract To evaluate changes in inner retinal layer (IRL) thicknesses in patients with type 1 diabetes mellitus (DM1) with no diabetic retinopathy (DR) using two different optical coherence tomography (OCT) devices. Ninety DM1 and 60 healthy eyes were evaluated using spectral domain (SD)-OCT and swept source (SS)-OCT to measure changes in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and inner nuclear layer (INL) thicknesses in all Early Treatment of Diabetic Retinopathy Study (ETDRS) macular areas. Functional tests were performed in both groups, including ETDRS with 100, 2.5 and 1.25% contrast, and color vision. The mean ages were 42.93 ± 13.62 and 41.52 ± 13.05 years in the diabetic and control groups, respectively. Visual acuity (VA) with ETDRS 1.25% was lower in the DM1 patients. Both ETDRS 2.5% and color vision were lower in the DM1 group but did not reach statistical significance. Retinal thicknesses in the central area and in the vertical outer areas were higher in the DM1 group. Differences were found in the IRL with no changes in the outer ones. Long-term DM1 patients with no DR maintained visual function, with a decrease in VA with 1.25% ETDRS contrast. Macular thickness measurements were higher using Spectralis SD-OCT than DRI Triton SS-OCT, and DM1 patients had a decrease in IRL thickness, especially in the GCL at the parafoveal level, generating thinning of the RNFL in the peripheral areas. There were no differences in outer retinal layer (ORL) thickness.
format	article
author	Elvira Orduna-Hospital Ana Sanchez-Cano Lorena Perdices Javier Acha Elena María Lopez-Alaminos Isabel Pinilla
author_facet	Elvira Orduna-Hospital Ana Sanchez-Cano Lorena Perdices Javier Acha Elena María Lopez-Alaminos Isabel Pinilla
author_sort	Elvira Orduna-Hospital
title	Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs
title_short	Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs
title_full	Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs
title_fullStr	Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs
title_full_unstemmed	Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs
title_sort	changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source octs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1af643e3d3a941d2ac98a1b87a775ef6
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Changes in retinal layers in type 1 diabetes mellitus without retinopathy measured by spectral domain and swept source OCTs

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