A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis

A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis

Camptothecin is a monoterpene indole alkaloid with anti-tumor activity. Here, the authors assemble the genome of the camptothecin producing plant Camptotheca acuminata and provide insights into the evolutionary origin of camptothecin biosynthesis by comparing to the vinblastine and vincristine biosy...

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Autores principales: Minghui Kang, Rao Fu, Pingyu Zhang, Shangling Lou, Xuchen Yang, Yang Chen, Tao Ma, Yang Zhang, Zhenxiang Xi, Jianquan Liu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/1af685523ed740b7bc6ddfecb3e3dea8
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spelling oai:doaj.org-article:1af685523ed740b7bc6ddfecb3e3dea82021-12-02T14:59:27ZA chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis10.1038/s41467-021-23872-92041-1723https://doaj.org/article/1af685523ed740b7bc6ddfecb3e3dea82021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23872-9https://doaj.org/toc/2041-1723Camptothecin is a monoterpene indole alkaloid with anti-tumor activity. Here, the authors assemble the genome of the camptothecin producing plant Camptotheca acuminata and provide insights into the evolutionary origin of camptothecin biosynthesis by comparing to the vinblastine and vincristine biosynthetic pathway in Catharanthus roseus.Minghui KangRao FuPingyu ZhangShangling LouXuchen YangYang ChenTao MaYang ZhangZhenxiang XiJianquan LiuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Minghui Kang
Rao Fu
Pingyu Zhang
Shangling Lou
Xuchen Yang
Yang Chen
Tao Ma
Yang Zhang
Zhenxiang Xi
Jianquan Liu
A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
description Camptothecin is a monoterpene indole alkaloid with anti-tumor activity. Here, the authors assemble the genome of the camptothecin producing plant Camptotheca acuminata and provide insights into the evolutionary origin of camptothecin biosynthesis by comparing to the vinblastine and vincristine biosynthetic pathway in Catharanthus roseus.
format article
author Minghui Kang
Rao Fu
Pingyu Zhang
Shangling Lou
Xuchen Yang
Yang Chen
Tao Ma
Yang Zhang
Zhenxiang Xi
Jianquan Liu
author_facet Minghui Kang
Rao Fu
Pingyu Zhang
Shangling Lou
Xuchen Yang
Yang Chen
Tao Ma
Yang Zhang
Zhenxiang Xi
Jianquan Liu
author_sort Minghui Kang
title A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
title_short A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
title_full A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
title_fullStr A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
title_full_unstemmed A chromosome-level Camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
title_sort chromosome-level camptotheca acuminata genome assembly provides insights into the evolutionary origin of camptothecin biosynthesis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/1af685523ed740b7bc6ddfecb3e3dea8
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