Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task

Cannabis use can be traced back to several centuries before the Common Era, when it was used for industrial, medicinal and recreational purposes. More recently, over 100 different cannabinoid compounds have been identified, one of which is cannabidiol (CBD), a compound widely used for anti-inflammat...

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Autores principales:	Éamon Jones, Styliani Vlachou
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	cannabidiol working memory cannabinoid cognition N-back task Medicine R Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1af793463ccd4a058443cf14a652f9c1
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spelling	oai:doaj.org-article:1af793463ccd4a058443cf14a652f9c12021-11-25T18:39:52ZCannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task10.3390/ph141111651424-8247https://doaj.org/article/1af793463ccd4a058443cf14a652f9c12021-11-01T00:00:00Zhttps://www.mdpi.com/1424-8247/14/11/1165https://doaj.org/toc/1424-8247Cannabis use can be traced back to several centuries before the Common Era, when it was used for industrial, medicinal and recreational purposes. More recently, over 100 different cannabinoid compounds have been identified, one of which is cannabidiol (CBD), a compound widely used for anti-inflammatory and anxiolytic treatment. The literature surrounding the cognitive effects of CBD is limited, with most studies focusing on the effects of other cannabinoids on cognition. To expand this literature, this study investigated whether CBD causes significant differences to working memory (WM) functioning, as measured by the N-back task. It was hypothesised that CBD does not cause statistically significant differences to WM. In all, 54 participants, 33 females and 21 males, were recruited, with a mean age of 32.63 years. Of these 54 participants, 26 reported using CBD and no other cannabinoids, while 28 reported not using any cannabinoid. The participants were instructed to answer a short online survey to gather basic demographic data and to complete an online N-back task to measure WM. For the computerised N-back task, the participants completed a practice and three test blocks, where they were instructed to respond to whether a series of letter stimuli were presented one trial back (1-back), two trials back (2-back) or three trials back (3-back). Multivariate analysis of covariance yielded no statistically significant difference on either response time or response accuracy data between groups after controlling for how long the participants use CBD and for what reason they use CBD. These results support our hypothesis that CBD does not cause significant changes to WM functioning. Further research is greatly needed to investigate the long-term effects of CBD use on WM and on general cognitive functioning.Éamon JonesStyliani VlachouMDPI AGarticlecannabidiolworking memorycannabinoidcognitionN-back taskMedicineRPharmacy and materia medicaRS1-441ENPharmaceuticals, Vol 14, Iss 1165, p 1165 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cannabidiol working memory cannabinoid cognition N-back task Medicine R Pharmacy and materia medica RS1-441
spellingShingle	cannabidiol working memory cannabinoid cognition N-back task Medicine R Pharmacy and materia medica RS1-441 Éamon Jones Styliani Vlachou Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task
description	Cannabis use can be traced back to several centuries before the Common Era, when it was used for industrial, medicinal and recreational purposes. More recently, over 100 different cannabinoid compounds have been identified, one of which is cannabidiol (CBD), a compound widely used for anti-inflammatory and anxiolytic treatment. The literature surrounding the cognitive effects of CBD is limited, with most studies focusing on the effects of other cannabinoids on cognition. To expand this literature, this study investigated whether CBD causes significant differences to working memory (WM) functioning, as measured by the N-back task. It was hypothesised that CBD does not cause statistically significant differences to WM. In all, 54 participants, 33 females and 21 males, were recruited, with a mean age of 32.63 years. Of these 54 participants, 26 reported using CBD and no other cannabinoids, while 28 reported not using any cannabinoid. The participants were instructed to answer a short online survey to gather basic demographic data and to complete an online N-back task to measure WM. For the computerised N-back task, the participants completed a practice and three test blocks, where they were instructed to respond to whether a series of letter stimuli were presented one trial back (1-back), two trials back (2-back) or three trials back (3-back). Multivariate analysis of covariance yielded no statistically significant difference on either response time or response accuracy data between groups after controlling for how long the participants use CBD and for what reason they use CBD. These results support our hypothesis that CBD does not cause significant changes to WM functioning. Further research is greatly needed to investigate the long-term effects of CBD use on WM and on general cognitive functioning.
format	article
author	Éamon Jones Styliani Vlachou
author_facet	Éamon Jones Styliani Vlachou
author_sort	Éamon Jones
title	Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task
title_short	Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task
title_full	Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task
title_fullStr	Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task
title_full_unstemmed	Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task
title_sort	cannabidiol does not cause significant changes to working memory performance in the n-back task
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1af793463ccd4a058443cf14a652f9c1
work_keys_str_mv	AT eamonjones cannabidioldoesnotcausesignificantchangestoworkingmemoryperformanceinthenbacktask AT stylianivlachou cannabidioldoesnotcausesignificantchangestoworkingmemoryperformanceinthenbacktask
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Cannabidiol Does Not Cause Significant Changes to Working Memory Performance in the N-Back Task

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