Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome

Abstract Cascade genetic testing provides a method to appropriately focus colonoscopy use in families with Lynch syndrome (LS). However, research suggests that up to two-thirds at risk to inherit LS don’t participate. Within the United States, no studies have assessed colonoscopy use within this elu...

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Autores principales:	Donald W. Hadley, Dina Eliezer, Yonit Addissie, Andrea Goergen, Sato Ashida, Laura Koehly
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1af8410c7b864d978d1859b9c261daf3
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spelling	oai:doaj.org-article:1af8410c7b864d978d1859b9c261daf32021-12-02T18:51:06ZUptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome10.1038/s41598-020-72938-z2045-2322https://doaj.org/article/1af8410c7b864d978d1859b9c261daf32020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-72938-zhttps://doaj.org/toc/2045-2322Abstract Cascade genetic testing provides a method to appropriately focus colonoscopy use in families with Lynch syndrome (LS). However, research suggests that up to two-thirds at risk to inherit LS don’t participate. Within the United States, no studies have assessed colonoscopy use within this elusive and high-risk subset. We set forth to (1) document colonoscopy use within those not undergoing genetic testing (NGT) and (2) identify factors associated with completing colonoscopy. Data came from a cross sectional survey of families with molecularly confirmed LS. One hundred seventy-six (176) adults participated; 47 of unknown variant status and 129 with variant status known (59 carriers/70 non-carriers). Despite a high level of awareness of LS (85%) and identical recommendations for colonoscopy, NGT reported significantly lower use of colonoscopy than carriers (47% vs. 73%; p = 0.003). Our results show that perceived risk to develop colon cancer (AOR = 1.99, p < 0.05) and physician recommendations (AOR = 7.64, p < 0.01) are significant predictors of colonoscopy use across all family members controlling for carrier status. Given these findings, health care providers, should assess patients’ perceived risk to develop cancer, assist them in adjusting risk perceptions and discuss recommendations for colonoscopy with all members in families with LS. Trial Registration Clinical Trials.gov Identifier: NCT00004210.Donald W. HadleyDina EliezerYonit AddissieAndrea GoergenSato AshidaLaura KoehlyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Donald W. Hadley Dina Eliezer Yonit Addissie Andrea Goergen Sato Ashida Laura Koehly Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
description	Abstract Cascade genetic testing provides a method to appropriately focus colonoscopy use in families with Lynch syndrome (LS). However, research suggests that up to two-thirds at risk to inherit LS don’t participate. Within the United States, no studies have assessed colonoscopy use within this elusive and high-risk subset. We set forth to (1) document colonoscopy use within those not undergoing genetic testing (NGT) and (2) identify factors associated with completing colonoscopy. Data came from a cross sectional survey of families with molecularly confirmed LS. One hundred seventy-six (176) adults participated; 47 of unknown variant status and 129 with variant status known (59 carriers/70 non-carriers). Despite a high level of awareness of LS (85%) and identical recommendations for colonoscopy, NGT reported significantly lower use of colonoscopy than carriers (47% vs. 73%; p = 0.003). Our results show that perceived risk to develop colon cancer (AOR = 1.99, p < 0.05) and physician recommendations (AOR = 7.64, p < 0.01) are significant predictors of colonoscopy use across all family members controlling for carrier status. Given these findings, health care providers, should assess patients’ perceived risk to develop cancer, assist them in adjusting risk perceptions and discuss recommendations for colonoscopy with all members in families with LS. Trial Registration Clinical Trials.gov Identifier: NCT00004210.
format	article
author	Donald W. Hadley Dina Eliezer Yonit Addissie Andrea Goergen Sato Ashida Laura Koehly
author_facet	Donald W. Hadley Dina Eliezer Yonit Addissie Andrea Goergen Sato Ashida Laura Koehly
author_sort	Donald W. Hadley
title	Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
title_short	Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
title_full	Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
title_fullStr	Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
title_full_unstemmed	Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome
title_sort	uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for lynch syndrome
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1af8410c7b864d978d1859b9c261daf3
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Uptake and predictors of colonoscopy use in family members not participating in cascade genetic testing for Lynch syndrome

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