Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

SARS-CoV-2 orf9b binds to the mitochondrial outer membrane protein TOM70 and has been linked to the suppression of interferon responses. Here, the authors characterize the interactions of SARS-CoV-2 orf9b and human TOM70 biochemically, and they determine the 2.2 Å crystal structure of the TOM70 cyto...

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Autores principales:	Xiaopan Gao, Kaixiang Zhu, Bo Qin, Vincent Olieric, Meitian Wang, Sheng Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1afb5a07dd2f43a8bbd098b9cba2c45e
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spelling	oai:doaj.org-article:1afb5a07dd2f43a8bbd098b9cba2c45e2021-12-02T17:15:21ZCrystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions10.1038/s41467-021-23118-82041-1723https://doaj.org/article/1afb5a07dd2f43a8bbd098b9cba2c45e2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23118-8https://doaj.org/toc/2041-1723SARS-CoV-2 orf9b binds to the mitochondrial outer membrane protein TOM70 and has been linked to the suppression of interferon responses. Here, the authors characterize the interactions of SARS-CoV-2 orf9b and human TOM70 biochemically, and they determine the 2.2 Å crystal structure of the TOM70 cytosolic domain with a bound SARS-CoV-2 orf9b peptide.Xiaopan GaoKaixiang ZhuBo QinVincent OliericMeitian WangSheng CuiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiaopan Gao Kaixiang Zhu Bo Qin Vincent Olieric Meitian Wang Sheng Cui Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
description	SARS-CoV-2 orf9b binds to the mitochondrial outer membrane protein TOM70 and has been linked to the suppression of interferon responses. Here, the authors characterize the interactions of SARS-CoV-2 orf9b and human TOM70 biochemically, and they determine the 2.2 Å crystal structure of the TOM70 cytosolic domain with a bound SARS-CoV-2 orf9b peptide.
format	article
author	Xiaopan Gao Kaixiang Zhu Bo Qin Vincent Olieric Meitian Wang Sheng Cui
author_facet	Xiaopan Gao Kaixiang Zhu Bo Qin Vincent Olieric Meitian Wang Sheng Cui
author_sort	Xiaopan Gao
title	Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
title_short	Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
title_full	Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
title_fullStr	Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
title_full_unstemmed	Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions
title_sort	crystal structure of sars-cov-2 orf9b in complex with human tom70 suggests unusual virus-host interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1afb5a07dd2f43a8bbd098b9cba2c45e
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Crystal structure of SARS-CoV-2 Orf9b in complex with human TOM70 suggests unusual virus-host interactions

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