Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice
PD-L1, the ligand for T-cell inhibitory receptor PD-1, can be expressed by various cell types in the tumour microenvironment. Here, the authors show that, in mouse models, the expression of PD-L1 from both cancerous and normal host immune cells is important for suppressing anti-tumour immune respons...
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Nature Portfolio
2017
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oai:doaj.org-article:1afbaeea25fd48089e499f52e8e8af6d2021-12-02T14:42:22ZTumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice10.1038/ncomms145722041-1723https://doaj.org/article/1afbaeea25fd48089e499f52e8e8af6d2017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14572https://doaj.org/toc/2041-1723PD-L1, the ligand for T-cell inhibitory receptor PD-1, can be expressed by various cell types in the tumour microenvironment. Here, the authors show that, in mouse models, the expression of PD-L1 from both cancerous and normal host immune cells is important for suppressing anti-tumour immune responses.Janet LauJeanne CheungArmando NavarroSteve LianoglouBenjamin HaleyKlara TotpalLaura SandersHartmut KoeppenPatrick CaplaziJacqueline McBrideHenry ChiuRebecca HongJane GroganVincent JavinalRobert YauchBryan IrvingMarcia BelvinIra MellmanJeong M. KimMaike SchmidtNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Janet Lau Jeanne Cheung Armando Navarro Steve Lianoglou Benjamin Haley Klara Totpal Laura Sanders Hartmut Koeppen Patrick Caplazi Jacqueline McBride Henry Chiu Rebecca Hong Jane Grogan Vincent Javinal Robert Yauch Bryan Irving Marcia Belvin Ira Mellman Jeong M. Kim Maike Schmidt Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice |
| description |
PD-L1, the ligand for T-cell inhibitory receptor PD-1, can be expressed by various cell types in the tumour microenvironment. Here, the authors show that, in mouse models, the expression of PD-L1 from both cancerous and normal host immune cells is important for suppressing anti-tumour immune responses. |
| format |
article |
| author |
Janet Lau Jeanne Cheung Armando Navarro Steve Lianoglou Benjamin Haley Klara Totpal Laura Sanders Hartmut Koeppen Patrick Caplazi Jacqueline McBride Henry Chiu Rebecca Hong Jane Grogan Vincent Javinal Robert Yauch Bryan Irving Marcia Belvin Ira Mellman Jeong M. Kim Maike Schmidt |
| author_facet |
Janet Lau Jeanne Cheung Armando Navarro Steve Lianoglou Benjamin Haley Klara Totpal Laura Sanders Hartmut Koeppen Patrick Caplazi Jacqueline McBride Henry Chiu Rebecca Hong Jane Grogan Vincent Javinal Robert Yauch Bryan Irving Marcia Belvin Ira Mellman Jeong M. Kim Maike Schmidt |
| author_sort |
Janet Lau |
| title |
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice |
| title_short |
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice |
| title_full |
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice |
| title_fullStr |
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice |
| title_full_unstemmed |
Tumour and host cell PD-L1 is required to mediate suppression of anti-tumour immunity in mice |
| title_sort |
tumour and host cell pd-l1 is required to mediate suppression of anti-tumour immunity in mice |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/1afbaeea25fd48089e499f52e8e8af6d |
| work_keys_str_mv |
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| _version_ |
1718389676119687168 |