Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome

Abstract The goal of this study is to reveal the hub genes and molecular mechanisms of the coronavirus disease 2019 (COVID‐19) acute respiratory distress syndrome (ARDS) based on the genome‐wide RNA sequencing dataset. The RNA sequencing dataset of COVID‐19 ARDS was obtained from GSE163426. A total...

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Autores principales:	Wangsheng Deng, Jiaxing Zeng, Shunyu Lu, Chaoqian Li
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	acute respiratory distress syndrome coronavirus disease 2019 GSE163426 hub genes molecular mechanism Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1afedd3b6d994d7a8067def6d6c98970
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spelling	oai:doaj.org-article:1afedd3b6d994d7a8067def6d6c989702021-11-05T12:10:49ZComprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome1751-88571751-884910.1049/syb2.12034https://doaj.org/article/1afedd3b6d994d7a8067def6d6c989702021-12-01T00:00:00Zhttps://doi.org/10.1049/syb2.12034https://doaj.org/toc/1751-8849https://doaj.org/toc/1751-8857Abstract The goal of this study is to reveal the hub genes and molecular mechanisms of the coronavirus disease 2019 (COVID‐19) acute respiratory distress syndrome (ARDS) based on the genome‐wide RNA sequencing dataset. The RNA sequencing dataset of COVID‐19 ARDS was obtained from GSE163426. A total of 270 differentially expressed genes (DEGs) were identified between COVID‐19 ARDS and control group patients. Functional enrichment analysis of DEGs suggests that these DEGs may be involved in the following biological processes: response to cytokine, G‐protein coupled receptor activity, ionotropic glutamate receptor signalling pathway and G‐protein coupled receptor signalling pathway. By using the weighted correlation network analysis approach to analyse these DEGs, 10 hub DEGs that may play an important role in COVID‐19 ARDS were identified. A total of 67 potential COVID‐19 ARDS targetted drugs were identified by a complement map analysis. Immune cell infiltration analysis revealed that the levels of T cells CD4 naive, T cells follicular helper, macrophages M1 and eosinophils in COVID‐19 ARDS patients were significantly different from those in control group patients. In conclusion, this study identified 10 COVID‐19 ARDS‐related hub DEGs and numerous potential molecular mechanisms through a comprehensive analysis of the RNA sequencing dataset and also revealed the difference in immune cell infiltration of COVID‐19 ARDS.Wangsheng DengJiaxing ZengShunyu LuChaoqian LiWileyarticleacute respiratory distress syndromecoronavirus disease 2019GSE163426hub genesmolecular mechanismBiology (General)QH301-705.5ENIET Systems Biology, Vol 15, Iss 6, Pp 205-218 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	acute respiratory distress syndrome coronavirus disease 2019 GSE163426 hub genes molecular mechanism Biology (General) QH301-705.5
spellingShingle	acute respiratory distress syndrome coronavirus disease 2019 GSE163426 hub genes molecular mechanism Biology (General) QH301-705.5 Wangsheng Deng Jiaxing Zeng Shunyu Lu Chaoqian Li Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome
description	Abstract The goal of this study is to reveal the hub genes and molecular mechanisms of the coronavirus disease 2019 (COVID‐19) acute respiratory distress syndrome (ARDS) based on the genome‐wide RNA sequencing dataset. The RNA sequencing dataset of COVID‐19 ARDS was obtained from GSE163426. A total of 270 differentially expressed genes (DEGs) were identified between COVID‐19 ARDS and control group patients. Functional enrichment analysis of DEGs suggests that these DEGs may be involved in the following biological processes: response to cytokine, G‐protein coupled receptor activity, ionotropic glutamate receptor signalling pathway and G‐protein coupled receptor signalling pathway. By using the weighted correlation network analysis approach to analyse these DEGs, 10 hub DEGs that may play an important role in COVID‐19 ARDS were identified. A total of 67 potential COVID‐19 ARDS targetted drugs were identified by a complement map analysis. Immune cell infiltration analysis revealed that the levels of T cells CD4 naive, T cells follicular helper, macrophages M1 and eosinophils in COVID‐19 ARDS patients were significantly different from those in control group patients. In conclusion, this study identified 10 COVID‐19 ARDS‐related hub DEGs and numerous potential molecular mechanisms through a comprehensive analysis of the RNA sequencing dataset and also revealed the difference in immune cell infiltration of COVID‐19 ARDS.
format	article
author	Wangsheng Deng Jiaxing Zeng Shunyu Lu Chaoqian Li
author_facet	Wangsheng Deng Jiaxing Zeng Shunyu Lu Chaoqian Li
author_sort	Wangsheng Deng
title	Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome
title_short	Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome
title_full	Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome
title_fullStr	Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome
title_full_unstemmed	Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome
title_sort	comprehensive investigation of rna‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/1afedd3b6d994d7a8067def6d6c98970
work_keys_str_mv	AT wangshengdeng comprehensiveinvestigationofrnasequencingdatasetrevealsthehubgenesandmolecularmechanismsofcoronavirusdisease2019acuterespiratorydistresssyndrome AT jiaxingzeng comprehensiveinvestigationofrnasequencingdatasetrevealsthehubgenesandmolecularmechanismsofcoronavirusdisease2019acuterespiratorydistresssyndrome AT shunyulu comprehensiveinvestigationofrnasequencingdatasetrevealsthehubgenesandmolecularmechanismsofcoronavirusdisease2019acuterespiratorydistresssyndrome AT chaoqianli comprehensiveinvestigationofrnasequencingdatasetrevealsthehubgenesandmolecularmechanismsofcoronavirusdisease2019acuterespiratorydistresssyndrome
_version_	1718444274143461376

Comprehensive investigation of RNA‐sequencing dataset reveals the hub genes and molecular mechanisms of coronavirus disease 2019 acute respiratory distress syndrome

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