Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation

Metazoan genomes contain many clusters of conserved noncoding elements. Here, the authors provide evidence that these clusters coincide with distinct topologically associating domains in humans and Drosophila, revealing a conserved regulatory genomic architecture.

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Autores principales:	Nathan Harmston, Elizabeth Ing-Simmons, Ge Tan, Malcolm Perry, Matthias Merkenschlager, Boris Lenhard
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b04c3b1a6a64b378ed9795e790183ff
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spelling	oai:doaj.org-article:1b04c3b1a6a64b378ed9795e790183ff2021-12-02T15:38:47ZTopologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation10.1038/s41467-017-00524-52041-1723https://doaj.org/article/1b04c3b1a6a64b378ed9795e790183ff2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00524-5https://doaj.org/toc/2041-1723Metazoan genomes contain many clusters of conserved noncoding elements. Here, the authors provide evidence that these clusters coincide with distinct topologically associating domains in humans and Drosophila, revealing a conserved regulatory genomic architecture.Nathan HarmstonElizabeth Ing-SimmonsGe TanMalcolm PerryMatthias MerkenschlagerBoris LenhardNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nathan Harmston Elizabeth Ing-Simmons Ge Tan Malcolm Perry Matthias Merkenschlager Boris Lenhard Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
description	Metazoan genomes contain many clusters of conserved noncoding elements. Here, the authors provide evidence that these clusters coincide with distinct topologically associating domains in humans and Drosophila, revealing a conserved regulatory genomic architecture.
format	article
author	Nathan Harmston Elizabeth Ing-Simmons Ge Tan Malcolm Perry Matthias Merkenschlager Boris Lenhard
author_facet	Nathan Harmston Elizabeth Ing-Simmons Ge Tan Malcolm Perry Matthias Merkenschlager Boris Lenhard
author_sort	Nathan Harmston
title	Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_short	Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_full	Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_fullStr	Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_full_unstemmed	Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation
title_sort	topologically associating domains are ancient features that coincide with metazoan clusters of extreme noncoding conservation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1b04c3b1a6a64b378ed9795e790183ff
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Topologically associating domains are ancient features that coincide with Metazoan clusters of extreme noncoding conservation

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