Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo

Detection of amyloid beta deposits is often performed with fluorescent compounds that bind plaques. Here the authors develop turn-on chemiluminescent probes that bind amyloid beta plaques in vivo, and amplify the signal via chemiluminescence resonance energy transfer to the plaque-binding fluorescen...

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Autores principales: Jing Yang, Wei Yin, Richard Van, Keyi Yin, Peng Wang, Chao Zheng, Biyue Zhu, Kathleen Ran, Can Zhang, Mohanraja Kumar, Yihan Shao, Chongzhao Ran
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/1b0e2d17a1284d778ce3f42a0c81effe
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spelling oai:doaj.org-article:1b0e2d17a1284d778ce3f42a0c81effe2021-12-02T18:51:02ZTurn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo10.1038/s41467-020-17783-42041-1723https://doaj.org/article/1b0e2d17a1284d778ce3f42a0c81effe2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17783-4https://doaj.org/toc/2041-1723Detection of amyloid beta deposits is often performed with fluorescent compounds that bind plaques. Here the authors develop turn-on chemiluminescent probes that bind amyloid beta plaques in vivo, and amplify the signal via chemiluminescence resonance energy transfer to the plaque-binding fluorescent molecule CRANAD-3.Jing YangWei YinRichard VanKeyi YinPeng WangChao ZhengBiyue ZhuKathleen RanCan ZhangMohanraja KumarYihan ShaoChongzhao RanNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jing Yang
Wei Yin
Richard Van
Keyi Yin
Peng Wang
Chao Zheng
Biyue Zhu
Kathleen Ran
Can Zhang
Mohanraja Kumar
Yihan Shao
Chongzhao Ran
Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
description Detection of amyloid beta deposits is often performed with fluorescent compounds that bind plaques. Here the authors develop turn-on chemiluminescent probes that bind amyloid beta plaques in vivo, and amplify the signal via chemiluminescence resonance energy transfer to the plaque-binding fluorescent molecule CRANAD-3.
format article
author Jing Yang
Wei Yin
Richard Van
Keyi Yin
Peng Wang
Chao Zheng
Biyue Zhu
Kathleen Ran
Can Zhang
Mohanraja Kumar
Yihan Shao
Chongzhao Ran
author_facet Jing Yang
Wei Yin
Richard Van
Keyi Yin
Peng Wang
Chao Zheng
Biyue Zhu
Kathleen Ran
Can Zhang
Mohanraja Kumar
Yihan Shao
Chongzhao Ran
author_sort Jing Yang
title Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
title_short Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
title_full Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
title_fullStr Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
title_full_unstemmed Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
title_sort turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/1b0e2d17a1284d778ce3f42a0c81effe
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