Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.

Immature fruits from Punica granatum L. thinning are a neglected side product of pomegranate production with cumbersome disposal costs for farmers. To explore value potential of immature fruits from pomegranate 'Wonderful' cultivars, the compositional landscapes and antitumorigenic activit...

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Autores principales:	Venera Russo, Alberto Continella, Carmelo Drago, Alessandra Gentile, Stefano La Malfa, Claudia Giovanna Leotta, Luana Pulvirenti, Giuseppe Ruberto, Giovanni Mario Pitari, Laura Siracusa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b0ea31e26c04f21b32200d0e486799c
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spelling	oai:doaj.org-article:1b0ea31e26c04f21b32200d0e486799c2021-12-02T20:18:27ZSecondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.1932-620310.1371/journal.pone.0255831https://doaj.org/article/1b0ea31e26c04f21b32200d0e486799c2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255831https://doaj.org/toc/1932-6203Immature fruits from Punica granatum L. thinning are a neglected side product of pomegranate production with cumbersome disposal costs for farmers. To explore value potential of immature fruits from pomegranate 'Wonderful' cultivars, the compositional landscapes and antitumorigenic activities of pomegranate extracts from two different stages of maturation were assessed. Cancer cell proliferation and cytotoxicity was quantified in human lung H1299 and colon HCT116 adenocarcinomas by crystal violet staining, MTS assay and caspase-3 activity. High performance liquid chromatography-diode array detector (HPLC/DAD) and high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC/ESI-MS) analyses indicate that immature fruits are rich sources of gallotannins and ellagitannins, with the highest amounts contained in immature fruit peels. Biological investigations reveal a robust anticancer activity by those immature P. granatum fruit extracts, which reflected induction of tumor cytotoxicity and cell death mechanisms. Together, present observations suggest P. granatum byproducts from the thinning process may provide unexplored values for virtuous circular economy.Venera RussoAlberto ContinellaCarmelo DragoAlessandra GentileStefano La MalfaClaudia Giovanna LeottaLuana PulvirentiGiuseppe RubertoGiovanni Mario PitariLaura SiracusaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255831 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Venera Russo Alberto Continella Carmelo Drago Alessandra Gentile Stefano La Malfa Claudia Giovanna Leotta Luana Pulvirenti Giuseppe Ruberto Giovanni Mario Pitari Laura Siracusa Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.
description	Immature fruits from Punica granatum L. thinning are a neglected side product of pomegranate production with cumbersome disposal costs for farmers. To explore value potential of immature fruits from pomegranate 'Wonderful' cultivars, the compositional landscapes and antitumorigenic activities of pomegranate extracts from two different stages of maturation were assessed. Cancer cell proliferation and cytotoxicity was quantified in human lung H1299 and colon HCT116 adenocarcinomas by crystal violet staining, MTS assay and caspase-3 activity. High performance liquid chromatography-diode array detector (HPLC/DAD) and high performance liquid chromatography-electrospray ionization-mass spectrometry (HPLC/ESI-MS) analyses indicate that immature fruits are rich sources of gallotannins and ellagitannins, with the highest amounts contained in immature fruit peels. Biological investigations reveal a robust anticancer activity by those immature P. granatum fruit extracts, which reflected induction of tumor cytotoxicity and cell death mechanisms. Together, present observations suggest P. granatum byproducts from the thinning process may provide unexplored values for virtuous circular economy.
format	article
author	Venera Russo Alberto Continella Carmelo Drago Alessandra Gentile Stefano La Malfa Claudia Giovanna Leotta Luana Pulvirenti Giuseppe Ruberto Giovanni Mario Pitari Laura Siracusa
author_facet	Venera Russo Alberto Continella Carmelo Drago Alessandra Gentile Stefano La Malfa Claudia Giovanna Leotta Luana Pulvirenti Giuseppe Ruberto Giovanni Mario Pitari Laura Siracusa
author_sort	Venera Russo
title	Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.
title_short	Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.
title_full	Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.
title_fullStr	Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.
title_full_unstemmed	Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.
title_sort	secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1b0ea31e26c04f21b32200d0e486799c
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Secondary metabolic profiles and anticancer actions from fruit extracts of immature pomegranates.

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