KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway

Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and its underlying mechanisms are still not fully understood. The epidermal growth factor receptor (EGFR) activation is an important event that regulates mitogenic signaling. EGFR signaling plays an important role i...

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Autores principales:	Lin Gao, Ru Zhao, Junmei Liu, Wenbo Zhang, Feifei Sun, Qianshuo Yin, Xin Wang, Meng Wang, Tingting Feng, Yiming Qin, Wenjie Cai, Qianni Li, Hanchen Dong, Xueqing Chen, Xueting Xiong, Hui Liu, Jing Hu, Weiwen Chen, Bo Han
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	KIF15 EGFR Cdc42 CRPC protein stability Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/1b1019cfeb5f457cab5f3e84145a13bb
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spelling	oai:doaj.org-article:1b1019cfeb5f457cab5f3e84145a13bb2021-11-04T05:55:36ZKIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway2234-943X10.3389/fonc.2021.679173https://doaj.org/article/1b1019cfeb5f457cab5f3e84145a13bb2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.679173/fullhttps://doaj.org/toc/2234-943XCastration-resistant prostate cancer (CRPC) continues to be a major clinical problem and its underlying mechanisms are still not fully understood. The epidermal growth factor receptor (EGFR) activation is an important event that regulates mitogenic signaling. EGFR signaling plays an important role in the transition from androgen dependence to castration-resistant state in prostate cancer (PCa). Kinesin family member 15 (KIF15) has been suggested to be overexpressed in multiple malignancies. Here, we demonstrate that KIF15 expression is elevated in CRPC. We show that KIF15 contributes to CRPC progression by enhancing the EGFR signaling pathway, which includes complex network intermediates such as mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT pathways. In CRPC tumors, increased expression of KIF15 is positively correlated with EGFR protein level. KIF15 binds to EGFR, and prevents EGFR proteins from degradation in a Cdc42-dependent manner. These findings highlight the key role of KIF15 in the development of CRPC and rationalize KIF15 as a potential therapeutic target.Lin GaoRu ZhaoJunmei LiuWenbo ZhangFeifei SunQianshuo YinXin WangMeng WangTingting FengYiming QinWenjie CaiQianni LiHanchen DongXueqing ChenXueting XiongHui LiuHui LiuJing HuJing HuWeiwen ChenBo HanBo HanFrontiers Media S.A.articleKIF15EGFRCdc42CRPCprotein stabilityNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	KIF15 EGFR Cdc42 CRPC protein stability Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	KIF15 EGFR Cdc42 CRPC protein stability Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Lin Gao Ru Zhao Junmei Liu Wenbo Zhang Feifei Sun Qianshuo Yin Xin Wang Meng Wang Tingting Feng Yiming Qin Wenjie Cai Qianni Li Hanchen Dong Xueqing Chen Xueting Xiong Hui Liu Hui Liu Jing Hu Jing Hu Weiwen Chen Bo Han Bo Han KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway
description	Castration-resistant prostate cancer (CRPC) continues to be a major clinical problem and its underlying mechanisms are still not fully understood. The epidermal growth factor receptor (EGFR) activation is an important event that regulates mitogenic signaling. EGFR signaling plays an important role in the transition from androgen dependence to castration-resistant state in prostate cancer (PCa). Kinesin family member 15 (KIF15) has been suggested to be overexpressed in multiple malignancies. Here, we demonstrate that KIF15 expression is elevated in CRPC. We show that KIF15 contributes to CRPC progression by enhancing the EGFR signaling pathway, which includes complex network intermediates such as mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT pathways. In CRPC tumors, increased expression of KIF15 is positively correlated with EGFR protein level. KIF15 binds to EGFR, and prevents EGFR proteins from degradation in a Cdc42-dependent manner. These findings highlight the key role of KIF15 in the development of CRPC and rationalize KIF15 as a potential therapeutic target.
format	article
author	Lin Gao Ru Zhao Junmei Liu Wenbo Zhang Feifei Sun Qianshuo Yin Xin Wang Meng Wang Tingting Feng Yiming Qin Wenjie Cai Qianni Li Hanchen Dong Xueqing Chen Xueting Xiong Hui Liu Hui Liu Jing Hu Jing Hu Weiwen Chen Bo Han Bo Han
author_facet	Lin Gao Ru Zhao Junmei Liu Wenbo Zhang Feifei Sun Qianshuo Yin Xin Wang Meng Wang Tingting Feng Yiming Qin Wenjie Cai Qianni Li Hanchen Dong Xueqing Chen Xueting Xiong Hui Liu Hui Liu Jing Hu Jing Hu Weiwen Chen Bo Han Bo Han
author_sort	Lin Gao
title	KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway
title_short	KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway
title_full	KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway
title_fullStr	KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway
title_full_unstemmed	KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway
title_sort	kif15 promotes progression of castration resistant prostate cancer by activating egfr signaling pathway
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1b1019cfeb5f457cab5f3e84145a13bb
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KIF15 Promotes Progression of Castration Resistant Prostate Cancer by Activating EGFR Signaling Pathway

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