Radiosynovectomy in routine care: an old tool with modern applications

Objectives: Radiosynovectomy can be an effective treatment for difficult-to-treat monoarthritis resistant to systemic and local standard therapy. The objective of our study was to determine predictors of good response to radiosynovectomy in routine care and give an overview of this underused techniq...

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Autores principales:	Liz R. Caballero Motta, Ana M. Anzola Alfaro, Iustina Janta, Juan Molina Collada, Yulieth Katherine Henao, Rebeca Pérez Pascual, José María Álvaro-Gracia, Juan Carlos Nieto-González
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/1b114513c63b464d98e28f083260848b
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spelling	oai:doaj.org-article:1b114513c63b464d98e28f083260848b2021-12-01T00:06:54ZRadiosynovectomy in routine care: an old tool with modern applications1759-721810.1177/1759720X211055309https://doaj.org/article/1b114513c63b464d98e28f083260848b2021-11-01T00:00:00Zhttps://doi.org/10.1177/1759720X211055309https://doaj.org/toc/1759-7218Objectives: Radiosynovectomy can be an effective treatment for difficult-to-treat monoarthritis resistant to systemic and local standard therapy. The objective of our study was to determine predictors of good response to radiosynovectomy in routine care and give an overview of this underused technique. Methods: Retrospective observational study of all the patients who underwent radiosynovectomy during a 6-year inclusion period. All the procedures were ultrasound guided and the radiopharmaceutical used was chosen according to joint size. The patient was considered to have an effective response to radiosynovectomy if the attending physician reported a positive outcome and there was no need to increase local and or systemic treatment due to arthritis in the affected joint during the next 12 months following the procedure. Results: We included 67 patients who underwent radiosynovectomy in the knee (73.1%), wrist (16.4%), and elbow (10.5%). Overall, 44 (65.7%) procedures were considered effective. In the multivariate analysis, infiltration of wrists (odds ratio = 0.192; confidence interval = 0.046–0.79) and pigmented villonodular synovitis (odds ratio = 0.13; confidence interval = 0.021–0.82) were independently associated with a noneffective response. No patients experienced complications associated with radiosynovectomy during follow-up. Conclusion: Infiltrations of wrists with joint damage seem less likely to have a response to radiosynovectomy. In pigmented villonodular synovitis, radiosynovectomy as an adjuvant therapy for relapse might not be effective when performed more than 6 months after surgery. Overall, radiosynovectomy is an effective and safe treatment for persistent monoarthritis.Liz R. Caballero MottaAna M. Anzola AlfaroIustina JantaJuan Molina ColladaYulieth Katherine HenaoRebeca Pérez PascualJosé María Álvaro-GraciaJuan Carlos Nieto-GonzálezSAGE PublishingarticleDiseases of the musculoskeletal systemRC925-935ENTherapeutic Advances in Musculoskeletal Disease, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the musculoskeletal system RC925-935
spellingShingle	Diseases of the musculoskeletal system RC925-935 Liz R. Caballero Motta Ana M. Anzola Alfaro Iustina Janta Juan Molina Collada Yulieth Katherine Henao Rebeca Pérez Pascual José María Álvaro-Gracia Juan Carlos Nieto-González Radiosynovectomy in routine care: an old tool with modern applications
description	Objectives: Radiosynovectomy can be an effective treatment for difficult-to-treat monoarthritis resistant to systemic and local standard therapy. The objective of our study was to determine predictors of good response to radiosynovectomy in routine care and give an overview of this underused technique. Methods: Retrospective observational study of all the patients who underwent radiosynovectomy during a 6-year inclusion period. All the procedures were ultrasound guided and the radiopharmaceutical used was chosen according to joint size. The patient was considered to have an effective response to radiosynovectomy if the attending physician reported a positive outcome and there was no need to increase local and or systemic treatment due to arthritis in the affected joint during the next 12 months following the procedure. Results: We included 67 patients who underwent radiosynovectomy in the knee (73.1%), wrist (16.4%), and elbow (10.5%). Overall, 44 (65.7%) procedures were considered effective. In the multivariate analysis, infiltration of wrists (odds ratio = 0.192; confidence interval = 0.046–0.79) and pigmented villonodular synovitis (odds ratio = 0.13; confidence interval = 0.021–0.82) were independently associated with a noneffective response. No patients experienced complications associated with radiosynovectomy during follow-up. Conclusion: Infiltrations of wrists with joint damage seem less likely to have a response to radiosynovectomy. In pigmented villonodular synovitis, radiosynovectomy as an adjuvant therapy for relapse might not be effective when performed more than 6 months after surgery. Overall, radiosynovectomy is an effective and safe treatment for persistent monoarthritis.
format	article
author	Liz R. Caballero Motta Ana M. Anzola Alfaro Iustina Janta Juan Molina Collada Yulieth Katherine Henao Rebeca Pérez Pascual José María Álvaro-Gracia Juan Carlos Nieto-González
author_facet	Liz R. Caballero Motta Ana M. Anzola Alfaro Iustina Janta Juan Molina Collada Yulieth Katherine Henao Rebeca Pérez Pascual José María Álvaro-Gracia Juan Carlos Nieto-González
author_sort	Liz R. Caballero Motta
title	Radiosynovectomy in routine care: an old tool with modern applications
title_short	Radiosynovectomy in routine care: an old tool with modern applications
title_full	Radiosynovectomy in routine care: an old tool with modern applications
title_fullStr	Radiosynovectomy in routine care: an old tool with modern applications
title_full_unstemmed	Radiosynovectomy in routine care: an old tool with modern applications
title_sort	radiosynovectomy in routine care: an old tool with modern applications
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/1b114513c63b464d98e28f083260848b
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Radiosynovectomy in routine care: an old tool with modern applications

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