Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157
Due to endothelial impairment, high-dose lithium may produce an occlusive-like syndrome, comparable to permanent occlusion of major vessel-induced syndromes in rats; intracranial, portal, and caval hypertension, and aortal hypotension; multi-organ dysfunction syndrome; brain, heart, lung, liver, kid...
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2021
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oai:doaj.org-article:1b147c59efab414c9d37d8ad87e8b9d42021-11-25T16:48:22ZOver-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 15710.3390/biomedicines91115062227-9059https://doaj.org/article/1b147c59efab414c9d37d8ad87e8b9d42021-10-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1506https://doaj.org/toc/2227-9059Due to endothelial impairment, high-dose lithium may produce an occlusive-like syndrome, comparable to permanent occlusion of major vessel-induced syndromes in rats; intracranial, portal, and caval hypertension, and aortal hypotension; multi-organ dysfunction syndrome; brain, heart, lung, liver, kidney, and gastrointestinal lesions; arterial and venous thrombosis; and tissue oxidative stress. Stable gastric pentadecapeptide BPC 157 may be a means of therapy via activating loops (bypassing vessel occlusion) and counteracting major occlusion syndromes. Recently, BPC 157 counteracted the lithium sulfate regimen in rats (500 mg/kg/day, ip, for 3 days, with assessment at 210 min after each administration of lithium) and its severe syndrome (muscular weakness and prostration, reduced muscle fibers, myocardial infarction, and edema of various brain areas). Subsequently, BPC 157 also counteracted the lithium-induced occlusive-like syndrome; rapidly counteracted brain swelling and intracranial (superior sagittal sinus) hypertension, portal hypertension, and aortal hypotension, which otherwise would persist; counteracted vessel failure; abrogated congestion of the inferior caval and superior mesenteric veins; reversed azygos vein failure; and mitigated thrombosis (superior mesenteric vein and artery), congestion of the stomach, and major hemorrhagic lesions. Both regimens of BPC 157 administration also counteracted the previously described muscular weakness and prostration (as shown in microscopic and ECG recordings), myocardial congestion and infarction, in addition to edema and lesions in various brain areas; marked dilatation and central venous congestion in the liver; large areas of congestion and hemorrhage in the lung; and degeneration of proximal and distal tubules with cytoplasmic vacuolization in the kidney, attenuating oxidative stress. Thus, BPC 157 therapy overwhelmed high-dose lithium intoxication in rats.Sanja StrbeSlaven GojkovicIvan KrezicHelena ZizekHrvoje VranesIvan BarisicDean StrinicTatjana OrctJaksa VukojevicSpomenko IlicEva LovricDarija MuzinicDanijela KolencIgor FilipčićZoran ZoricicDarko MarcinkoAlenka Boban BlagaicAnita SkrticSven SeiwerthPredrag SikiricMDPI AGarticlelithium toxicityocclusive-like syndromeratsgastric pentadecapeptide BPC 157Biology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1506, p 1506 (2021) |
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lithium toxicity occlusive-like syndrome rats gastric pentadecapeptide BPC 157 Biology (General) QH301-705.5 |
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lithium toxicity occlusive-like syndrome rats gastric pentadecapeptide BPC 157 Biology (General) QH301-705.5 Sanja Strbe Slaven Gojkovic Ivan Krezic Helena Zizek Hrvoje Vranes Ivan Barisic Dean Strinic Tatjana Orct Jaksa Vukojevic Spomenko Ilic Eva Lovric Darija Muzinic Danijela Kolenc Igor Filipčić Zoran Zoricic Darko Marcinko Alenka Boban Blagaic Anita Skrtic Sven Seiwerth Predrag Sikiric Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157 |
| description |
Due to endothelial impairment, high-dose lithium may produce an occlusive-like syndrome, comparable to permanent occlusion of major vessel-induced syndromes in rats; intracranial, portal, and caval hypertension, and aortal hypotension; multi-organ dysfunction syndrome; brain, heart, lung, liver, kidney, and gastrointestinal lesions; arterial and venous thrombosis; and tissue oxidative stress. Stable gastric pentadecapeptide BPC 157 may be a means of therapy via activating loops (bypassing vessel occlusion) and counteracting major occlusion syndromes. Recently, BPC 157 counteracted the lithium sulfate regimen in rats (500 mg/kg/day, ip, for 3 days, with assessment at 210 min after each administration of lithium) and its severe syndrome (muscular weakness and prostration, reduced muscle fibers, myocardial infarction, and edema of various brain areas). Subsequently, BPC 157 also counteracted the lithium-induced occlusive-like syndrome; rapidly counteracted brain swelling and intracranial (superior sagittal sinus) hypertension, portal hypertension, and aortal hypotension, which otherwise would persist; counteracted vessel failure; abrogated congestion of the inferior caval and superior mesenteric veins; reversed azygos vein failure; and mitigated thrombosis (superior mesenteric vein and artery), congestion of the stomach, and major hemorrhagic lesions. Both regimens of BPC 157 administration also counteracted the previously described muscular weakness and prostration (as shown in microscopic and ECG recordings), myocardial congestion and infarction, in addition to edema and lesions in various brain areas; marked dilatation and central venous congestion in the liver; large areas of congestion and hemorrhage in the lung; and degeneration of proximal and distal tubules with cytoplasmic vacuolization in the kidney, attenuating oxidative stress. Thus, BPC 157 therapy overwhelmed high-dose lithium intoxication in rats. |
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article |
| author |
Sanja Strbe Slaven Gojkovic Ivan Krezic Helena Zizek Hrvoje Vranes Ivan Barisic Dean Strinic Tatjana Orct Jaksa Vukojevic Spomenko Ilic Eva Lovric Darija Muzinic Danijela Kolenc Igor Filipčić Zoran Zoricic Darko Marcinko Alenka Boban Blagaic Anita Skrtic Sven Seiwerth Predrag Sikiric |
| author_facet |
Sanja Strbe Slaven Gojkovic Ivan Krezic Helena Zizek Hrvoje Vranes Ivan Barisic Dean Strinic Tatjana Orct Jaksa Vukojevic Spomenko Ilic Eva Lovric Darija Muzinic Danijela Kolenc Igor Filipčić Zoran Zoricic Darko Marcinko Alenka Boban Blagaic Anita Skrtic Sven Seiwerth Predrag Sikiric |
| author_sort |
Sanja Strbe |
| title |
Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157 |
| title_short |
Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157 |
| title_full |
Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157 |
| title_fullStr |
Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157 |
| title_full_unstemmed |
Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157 |
| title_sort |
over-dose lithium toxicity as an occlusive-like syndrome in rats and gastric pentadecapeptide bpc 157 |
| publisher |
MDPI AG |
| publishDate |
2021 |
| url |
https://doaj.org/article/1b147c59efab414c9d37d8ad87e8b9d4 |
| work_keys_str_mv |
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