Canonical and Non-Canonical Roles of PFKFB3 in Brain Tumors
PFKFB3 is a bifunctional enzyme that modulates and maintains the intracellular concentrations of fructose-2,6-bisphosphate (F2,6-P2), essentially controlling the rate of glycolysis. PFKFB3 is a known activator of glycolytic rewiring in neoplastic cells, including central nervous system (CNS) neoplas...
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Autores principales: | Reinier Alvarez, Debjani Mandal, Prashant Chittiboina |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/1b1980bd9c8a4433aaa7491ce614c0ba |
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