Diverse MR1-restricted T cells in mice and humans

Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found in both Traj33-deficient mice and human periph...

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Autores principales:	Hui-Fern Koay, Nicholas A. Gherardin, Calvin Xu, Rebecca Seneviratna, Zhe Zhao, Zhenjun Chen, David P. Fairlie, James McCluskey, Daniel G. Pellicci, Adam P. Uldrich, Dale I. Godfrey
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b1b3b4abd8747eea3ce8b9c98588996
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spelling	oai:doaj.org-article:1b1b3b4abd8747eea3ce8b9c985889962021-12-02T15:36:03ZDiverse MR1-restricted T cells in mice and humans10.1038/s41467-019-10198-w2041-1723https://doaj.org/article/1b1b3b4abd8747eea3ce8b9c985889962019-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10198-whttps://doaj.org/toc/2041-1723Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found in both Traj33-deficient mice and human peripheral blood.Hui-Fern KoayNicholas A. GherardinCalvin XuRebecca SeneviratnaZhe ZhaoZhenjun ChenDavid P. FairlieJames McCluskeyDaniel G. PellicciAdam P. UldrichDale I. GodfreyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hui-Fern Koay Nicholas A. Gherardin Calvin Xu Rebecca Seneviratna Zhe Zhao Zhenjun Chen David P. Fairlie James McCluskey Daniel G. Pellicci Adam P. Uldrich Dale I. Godfrey Diverse MR1-restricted T cells in mice and humans
description	Mucosal-associated invariant T (MAIT) cells express invariant TRAV1/TRAJ33 TCR-α gene segments and detect antigens presented by MR1. Here the authors show that atypical, MR1-restricted MAIT populations that include both Trav1+ and Trav1- cells are found in both Traj33-deficient mice and human peripheral blood.
format	article
author	Hui-Fern Koay Nicholas A. Gherardin Calvin Xu Rebecca Seneviratna Zhe Zhao Zhenjun Chen David P. Fairlie James McCluskey Daniel G. Pellicci Adam P. Uldrich Dale I. Godfrey
author_facet	Hui-Fern Koay Nicholas A. Gherardin Calvin Xu Rebecca Seneviratna Zhe Zhao Zhenjun Chen David P. Fairlie James McCluskey Daniel G. Pellicci Adam P. Uldrich Dale I. Godfrey
author_sort	Hui-Fern Koay
title	Diverse MR1-restricted T cells in mice and humans
title_short	Diverse MR1-restricted T cells in mice and humans
title_full	Diverse MR1-restricted T cells in mice and humans
title_fullStr	Diverse MR1-restricted T cells in mice and humans
title_full_unstemmed	Diverse MR1-restricted T cells in mice and humans
title_sort	diverse mr1-restricted t cells in mice and humans
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1b1b3b4abd8747eea3ce8b9c98588996
work_keys_str_mv	AT huifernkoay diversemr1restrictedtcellsinmiceandhumans AT nicholasagherardin diversemr1restrictedtcellsinmiceandhumans AT calvinxu diversemr1restrictedtcellsinmiceandhumans AT rebeccaseneviratna diversemr1restrictedtcellsinmiceandhumans AT zhezhao diversemr1restrictedtcellsinmiceandhumans AT zhenjunchen diversemr1restrictedtcellsinmiceandhumans AT davidpfairlie diversemr1restrictedtcellsinmiceandhumans AT jamesmccluskey diversemr1restrictedtcellsinmiceandhumans AT danielgpellicci diversemr1restrictedtcellsinmiceandhumans AT adampuldrich diversemr1restrictedtcellsinmiceandhumans AT daleigodfrey diversemr1restrictedtcellsinmiceandhumans
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Diverse MR1-restricted T cells in mice and humans

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