PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

PICK1 deficiency impairs secretory vesicle biogenesis and leads to growth retardation and decreased glucose tolerance.

Secretory vesicles in endocrine cells store hormones such as growth hormone (GH) and insulin before their release into the bloodstream. The molecular mechanisms governing budding of immature secretory vesicles from the trans-Golgi network (TGN) and their subsequent maturation remain unclear. Here, w...

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Autores principales: Birgitte Holst, Kenneth L Madsen, Anna M Jansen, Chunyu Jin, Mattias Rickhag, Viktor K Lund, Morten Jensen, Vikram Bhatia, Gunnar Sørensen, Andreas N Madsen, Zhichao Xue, Siri K Møller, David Woldbye, Klaus Qvortrup, Richard Huganir, Dimitrios Stamou, Ole Kjærulff, Ulrik Gether
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
Materias:
Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/1b1e37beba824678913f7f38cf8eb86b
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