Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C

During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation. Here, the authors define the underlying mechanism and reveal that cyclin A2 engages the APC/C in multiple bindin...

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Autores principales:	Suyang Zhang, Thomas Tischer, David Barford
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b21bf467c2b4a78811b873283e83ee1
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id	oai:doaj.org-article:1b21bf467c2b4a78811b873283e83ee1
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spelling	oai:doaj.org-article:1b21bf467c2b4a78811b873283e83ee12021-12-02T17:02:00ZCyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C10.1038/s41467-019-11833-22041-1723https://doaj.org/article/1b21bf467c2b4a78811b873283e83ee12019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11833-2https://doaj.org/toc/2041-1723During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation. Here, the authors define the underlying mechanism and reveal that cyclin A2 engages the APC/C in multiple binding modes.Suyang ZhangThomas TischerDavid BarfordNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Suyang Zhang Thomas Tischer David Barford Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
description	During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation. Here, the authors define the underlying mechanism and reveal that cyclin A2 engages the APC/C in multiple binding modes.
format	article
author	Suyang Zhang Thomas Tischer David Barford
author_facet	Suyang Zhang Thomas Tischer David Barford
author_sort	Suyang Zhang
title	Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
title_short	Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
title_full	Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
title_fullStr	Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
title_full_unstemmed	Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C
title_sort	cyclin a2 degradation during the spindle assembly checkpoint requires multiple binding modes to the apc/c
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1b21bf467c2b4a78811b873283e83ee1
work_keys_str_mv	AT suyangzhang cyclina2degradationduringthespindleassemblycheckpointrequiresmultiplebindingmodestotheapcc AT thomastischer cyclina2degradationduringthespindleassemblycheckpointrequiresmultiplebindingmodestotheapcc AT davidbarford cyclina2degradationduringthespindleassemblycheckpointrequiresmultiplebindingmodestotheapcc
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Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C

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