Cyclin A2 degradation during the spindle assembly checkpoint requires multiple binding modes to the APC/C

During the spindle assembly checkpoint, the activity of the anaphase promoting complex/cyclosome (APC/C) is repressed, yet cyclin A2 evades the checkpoint and is targeted for degradation. Here, the authors define the underlying mechanism and reveal that cyclin A2 engages the APC/C in multiple bindin...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Suyang Zhang, Thomas Tischer, David Barford
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Q
Acceso en línea:https://doaj.org/article/1b21bf467c2b4a78811b873283e83ee1
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares