Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.

Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardio-pulmonary syndrome (HCPS; also called hantavirus pulmonary syndrome (HPS)), both human diseases with high case-fatality rates. Endothelial cells are the main targets for hantaviruses. An intriguing observation in p...

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Autores principales:	Shawon Gupta, Monika Braun, Nicole D Tischler, Malin Stoltz, Karin B Sundström, Niklas K Björkström, Hans-Gustaf Ljunggren, Jonas Klingström
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1b22078f2aa1413caf87523ca18aa9f1
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spelling	oai:doaj.org-article:1b22078f2aa1413caf87523ca18aa9f12021-11-18T06:05:51ZHantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.1553-73661553-737410.1371/journal.ppat.1003272https://doaj.org/article/1b22078f2aa1413caf87523ca18aa9f12013-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23555267/pdf/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardio-pulmonary syndrome (HCPS; also called hantavirus pulmonary syndrome (HPS)), both human diseases with high case-fatality rates. Endothelial cells are the main targets for hantaviruses. An intriguing observation in patients with HFRS and HCPS is that on one hand the virus infection leads to strong activation of CD8 T cells and NK cells, on the other hand no obvious destruction of infected endothelial cells is observed. Here, we provide an explanation for this dichotomy by showing that hantavirus-infected endothelial cells are protected from cytotoxic lymphocyte-mediated induction of apoptosis. When dissecting potential mechanisms behind this phenomenon, we discovered that the hantavirus nucleocapsid protein inhibits the enzymatic activity of both granzyme B and caspase 3. This provides a tentative explanation for the hantavirus-mediated block of cytotoxic granule-mediated apoptosis-induction, and hence the protection of infected cells from cytotoxic lymphocytes. These findings may explain why infected endothelial cells in hantavirus-infected patients are not destroyed by the strong cytotoxic lymphocyte response.Shawon GuptaMonika BraunNicole D TischlerMalin StoltzKarin B SundströmNiklas K BjörkströmHans-Gustaf LjunggrenJonas KlingströmPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 9, Iss 3, p e1003272 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5
spellingShingle	Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Shawon Gupta Monika Braun Nicole D Tischler Malin Stoltz Karin B Sundström Niklas K Björkström Hans-Gustaf Ljunggren Jonas Klingström Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
description	Hantaviruses cause hemorrhagic fever with renal syndrome (HFRS) and hantavirus cardio-pulmonary syndrome (HCPS; also called hantavirus pulmonary syndrome (HPS)), both human diseases with high case-fatality rates. Endothelial cells are the main targets for hantaviruses. An intriguing observation in patients with HFRS and HCPS is that on one hand the virus infection leads to strong activation of CD8 T cells and NK cells, on the other hand no obvious destruction of infected endothelial cells is observed. Here, we provide an explanation for this dichotomy by showing that hantavirus-infected endothelial cells are protected from cytotoxic lymphocyte-mediated induction of apoptosis. When dissecting potential mechanisms behind this phenomenon, we discovered that the hantavirus nucleocapsid protein inhibits the enzymatic activity of both granzyme B and caspase 3. This provides a tentative explanation for the hantavirus-mediated block of cytotoxic granule-mediated apoptosis-induction, and hence the protection of infected cells from cytotoxic lymphocytes. These findings may explain why infected endothelial cells in hantavirus-infected patients are not destroyed by the strong cytotoxic lymphocyte response.
format	article
author	Shawon Gupta Monika Braun Nicole D Tischler Malin Stoltz Karin B Sundström Niklas K Björkström Hans-Gustaf Ljunggren Jonas Klingström
author_facet	Shawon Gupta Monika Braun Nicole D Tischler Malin Stoltz Karin B Sundström Niklas K Björkström Hans-Gustaf Ljunggren Jonas Klingström
author_sort	Shawon Gupta
title	Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
title_short	Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
title_full	Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
title_fullStr	Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
title_full_unstemmed	Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
title_sort	hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1b22078f2aa1413caf87523ca18aa9f1
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Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis.

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