Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)

Synthetic cannabinoids are commonly known as Gorillas Tobacco, Hanomans Tobacco or Ganeshas Tobacco in Indonesia. Those products are camouflaged as a tobacco related to the number of smokers in Indonesia. The 5F-ADB (5F-MDMB-PINACA) has become an issue since 2016. It was undetectable by conventional...

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Autores principales:	Rieska Dwi Widayati, Tanti Tanti, Erlana Nindya Maulida, Martin Luther Silubun
Formato:	article
Lenguaje:	EN
Publicado:	University of Brawijaya 2020
Materias:	synthetic cannabinoids extrelut® column nt3 lc-hrms 5f-adb 5f-adb metabolite 7 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/1b22852d19fe42b6aa79ff100d717153
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spelling	oai:doaj.org-article:1b22852d19fe42b6aa79ff100d7171532021-12-02T16:39:16ZIdentification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)2302-46902302-4690https://doaj.org/article/1b22852d19fe42b6aa79ff100d7171532020-08-01T00:00:00Zhttps://jpacr.ub.ac.id/index.php/jpacr/article/view/537/pdf_1https://doaj.org/toc/2302-4690https://doaj.org/toc/2302-4690Synthetic cannabinoids are commonly known as Gorillas Tobacco, Hanomans Tobacco or Ganeshas Tobacco in Indonesia. Those products are camouflaged as a tobacco related to the number of smokers in Indonesia. The 5F-ADB (5F-MDMB-PINACA) has become an issue since 2016. It was undetectable by conventional drug testing methodology such as immunoassay method. GC-MS as a routine method analysis is not recommended also for detecting the metabolites from biological specimen with low concentration. The paper report LC-HRMS based method for identification of 5F-ADB and its metabolites in urine sample. Various of volume injections (1, 3, and 6 µL) was studied. Sample was acidified with concentrate of HCl, then undergo extraction with EXtrelut® Column NT3 prior to LC-HRMS analysis. The full method was operated for MS/dd-MS2 identification. The 5F-ADB and its ester hydrolysis metabolite, 5F-ADB metabolite 7 (C19H27FN3O3+) was detected in urine sampleRieska Dwi Widayati Tanti TantiErlana Nindya MaulidaMartin Luther SilubunUniversity of Brawijayaarticlesynthetic cannabinoidsextrelut® column nt3lc-hrms5f-adb5f-adb metabolite 7ChemistryQD1-999ENJournal of Pure and Applied Chemistry Research, Vol 9, Iss 2, Pp 91-97 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	synthetic cannabinoids extrelut® column nt3 lc-hrms 5f-adb 5f-adb metabolite 7 Chemistry QD1-999
spellingShingle	synthetic cannabinoids extrelut® column nt3 lc-hrms 5f-adb 5f-adb metabolite 7 Chemistry QD1-999 Rieska Dwi Widayati Tanti Tanti Erlana Nindya Maulida Martin Luther Silubun Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)
description	Synthetic cannabinoids are commonly known as Gorillas Tobacco, Hanomans Tobacco or Ganeshas Tobacco in Indonesia. Those products are camouflaged as a tobacco related to the number of smokers in Indonesia. The 5F-ADB (5F-MDMB-PINACA) has become an issue since 2016. It was undetectable by conventional drug testing methodology such as immunoassay method. GC-MS as a routine method analysis is not recommended also for detecting the metabolites from biological specimen with low concentration. The paper report LC-HRMS based method for identification of 5F-ADB and its metabolites in urine sample. Various of volume injections (1, 3, and 6 µL) was studied. Sample was acidified with concentrate of HCl, then undergo extraction with EXtrelut® Column NT3 prior to LC-HRMS analysis. The full method was operated for MS/dd-MS2 identification. The 5F-ADB and its ester hydrolysis metabolite, 5F-ADB metabolite 7 (C19H27FN3O3+) was detected in urine sample
format	article
author	Rieska Dwi Widayati Tanti Tanti Erlana Nindya Maulida Martin Luther Silubun
author_facet	Rieska Dwi Widayati Tanti Tanti Erlana Nindya Maulida Martin Luther Silubun
author_sort	Rieska Dwi Widayati
title	Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)
title_short	Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)
title_full	Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)
title_fullStr	Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)
title_full_unstemmed	Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)
title_sort	identification of synthetic cannabinoid 5f-adb (5f-mdmb-pinaca) and its metabolite in urine sample using liquid chromatography – high resolution mass spectrometer (lc-hrms)
publisher	University of Brawijaya
publishDate	2020
url	https://doaj.org/article/1b22852d19fe42b6aa79ff100d717153
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Identification of Synthetic Cannabinoid 5F-ADB (5F-MDMB-PINACA) and Its Metabolite in Urine Sample Using Liquid Chromatography – High Resolution Mass Spectrometer (LC-HRMS)

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