An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application to human iPSC-derived neurons, to compare the ne...

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Autores principales:	Ming Jin, Brian O’Nuallain, Wei Hong, Justin Boyd, Valentina N. Lagomarsino, Tiernan T. O’Malley, Wen Liu, Charles R. Vanderburg, Matthew P. Frosch, Tracy Young-Pearse, Dennis J. Selkoe, Dominic M. Walsh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b248bb1ced34f1e829628bfcb182dd4
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spelling	oai:doaj.org-article:1b248bb1ced34f1e829628bfcb182dd42021-12-02T15:33:44ZAn in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease10.1038/s41467-018-05068-w2041-1723https://doaj.org/article/1b248bb1ced34f1e829628bfcb182dd42018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05068-whttps://doaj.org/toc/2041-1723The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application to human iPSC-derived neurons, to compare the neuroprotective potential of several anti-Aβ antibodies.Ming JinBrian O’NuallainWei HongJustin BoydValentina N. LagomarsinoTiernan T. O’MalleyWen LiuCharles R. VanderburgMatthew P. FroschTracy Young-PearseDennis J. SelkoeDominic M. WalshNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ming Jin Brian O’Nuallain Wei Hong Justin Boyd Valentina N. Lagomarsino Tiernan T. O’Malley Wen Liu Charles R. Vanderburg Matthew P. Frosch Tracy Young-Pearse Dennis J. Selkoe Dominic M. Walsh An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
description	The optimal Aβ species to target for the potential treatment of Alzheimer’s disease has not yet been established. Here, the authors describe an in vitro assay that uses extracts from brain tissue from patients with Alzheimer’s disease, and application to human iPSC-derived neurons, to compare the neuroprotective potential of several anti-Aβ antibodies.
format	article
author	Ming Jin Brian O’Nuallain Wei Hong Justin Boyd Valentina N. Lagomarsino Tiernan T. O’Malley Wen Liu Charles R. Vanderburg Matthew P. Frosch Tracy Young-Pearse Dennis J. Selkoe Dominic M. Walsh
author_facet	Ming Jin Brian O’Nuallain Wei Hong Justin Boyd Valentina N. Lagomarsino Tiernan T. O’Malley Wen Liu Charles R. Vanderburg Matthew P. Frosch Tracy Young-Pearse Dennis J. Selkoe Dominic M. Walsh
author_sort	Ming Jin
title	An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
title_short	An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
title_full	An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
title_fullStr	An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
title_full_unstemmed	An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease
title_sort	in vitro paradigm to assess potential anti-aβ antibodies for alzheimer’s disease
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b248bb1ced34f1e829628bfcb182dd4
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An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer’s disease

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