Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases

After W.D. Miller proved a causal relationship between microbes and dental caries and periodontitis, the repair and replacement of damaged or lost teeth resulting from microbial activity dominated 20th century dental practice. In this study, I predict that in the 21st century dental practice will sh...

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Autor principal:	Edward F Rossomando
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	birth defects craniofacial anomalies crispr dysmorphogenesis Dentistry RK1-715
Acceso en línea:	https://doaj.org/article/1b24d7bc2e384e3a9eea77e90a4a1453
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spelling	oai:doaj.org-article:1b24d7bc2e384e3a9eea77e90a4a14532021-11-12T10:10:06ZTwenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases2155-821310.4103/denthyp.denthyp_120_21https://doaj.org/article/1b24d7bc2e384e3a9eea77e90a4a14532021-01-01T00:00:00Zhttp://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2021;volume=12;issue=3;spage=105;epage=108;aulast=Rossomandohttps://doaj.org/toc/2155-8213After W.D. Miller proved a causal relationship between microbes and dental caries and periodontitis, the repair and replacement of damaged or lost teeth resulting from microbial activity dominated 20th century dental practice. In this study, I predict that in the 21st century dental practice will shift to the treatment of those dental diseases not caused by microbes. As dentists already treat some nonmicrobial diseases, I will focus on craniofacial malformations, the group of nonmicrobial diseases usually called birth defects. Some examples include dental dysplasias, cleft lip and palate, and malocclusion. In this study, I introduce the word “dysmorphogenesis” (to replace the term birth defect) as it more appropriately ascribes this subset of nonmicrobial diseases results to mistakes during the formation of craniofacial structures. As dysmorphogenic diseases occur during gestation, their diagnosis and especially their treatment require intervention during embryogenesis. Fortunately, decades of research have shown that mutations are involved in malformations during amelogenesis, palatogenesis, and odontogenesis. Knowledge of which genes are involved, together with recent breakthroughs in Crispr gene editing, make interventions during gestation possible. Those dentists performing gene editing procedures I have previously called Biodontists, because creating the Biodontics specialty will take time. The dental profession including dental educators, dental practitioners, and dental manufacturers should begin discussions now on how best to proceed.Edward F RossomandoWolters Kluwer Medknow Publicationsarticlebirth defectscraniofacial anomaliescrisprdysmorphogenesisDentistryRK1-715ENDental Hypotheses, Vol 12, Iss 3, Pp 105-108 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	birth defects craniofacial anomalies crispr dysmorphogenesis Dentistry RK1-715
spellingShingle	birth defects craniofacial anomalies crispr dysmorphogenesis Dentistry RK1-715 Edward F Rossomando Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases
description	After W.D. Miller proved a causal relationship between microbes and dental caries and periodontitis, the repair and replacement of damaged or lost teeth resulting from microbial activity dominated 20th century dental practice. In this study, I predict that in the 21st century dental practice will shift to the treatment of those dental diseases not caused by microbes. As dentists already treat some nonmicrobial diseases, I will focus on craniofacial malformations, the group of nonmicrobial diseases usually called birth defects. Some examples include dental dysplasias, cleft lip and palate, and malocclusion. In this study, I introduce the word “dysmorphogenesis” (to replace the term birth defect) as it more appropriately ascribes this subset of nonmicrobial diseases results to mistakes during the formation of craniofacial structures. As dysmorphogenic diseases occur during gestation, their diagnosis and especially their treatment require intervention during embryogenesis. Fortunately, decades of research have shown that mutations are involved in malformations during amelogenesis, palatogenesis, and odontogenesis. Knowledge of which genes are involved, together with recent breakthroughs in Crispr gene editing, make interventions during gestation possible. Those dentists performing gene editing procedures I have previously called Biodontists, because creating the Biodontics specialty will take time. The dental profession including dental educators, dental practitioners, and dental manufacturers should begin discussions now on how best to proceed.
format	article
author	Edward F Rossomando
author_facet	Edward F Rossomando
author_sort	Edward F Rossomando
title	Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases
title_short	Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases
title_full	Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases
title_fullStr	Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases
title_full_unstemmed	Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases
title_sort	twenty-first century dental practice and the treatment of nonmicrobial genetic-based dental diseases
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/1b24d7bc2e384e3a9eea77e90a4a1453
work_keys_str_mv	AT edwardfrossomando twentyfirstcenturydentalpracticeandthetreatmentofnonmicrobialgeneticbaseddentaldiseases
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Twenty-first Century Dental Practice and the Treatment of Nonmicrobial Genetic-based Dental Diseases

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