The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases

Abstract Cerebral hypoperfusion impairs brain activity and leads to cognitive impairment. Left and right common carotid arteries (CCA) are the major source of cerebral blood supply. It remains unclear whether blood flow in both CCA contributes equally to brain activity. Here, CCA blood flow was eval...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Takahiro Matsumoto, Hideyuki Hoshi, Yoko Hirata, Sayuri Ichikawa, Keisuke Fukasawa, Tomoyuki Gonda, Jesús Poza, Víctor Rodríguez-González, Carlos Gómez, Yoshihito Shigihara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b24f3928ef34fe79a9065ef17d2cec0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1b24f3928ef34fe79a9065ef17d2cec0
record_format	dspace
spelling	oai:doaj.org-article:1b24f3928ef34fe79a9065ef17d2cec02021-12-02T16:06:44ZThe association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases10.1038/s41598-021-94717-02045-2322https://doaj.org/article/1b24f3928ef34fe79a9065ef17d2cec02021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94717-0https://doaj.org/toc/2045-2322Abstract Cerebral hypoperfusion impairs brain activity and leads to cognitive impairment. Left and right common carotid arteries (CCA) are the major source of cerebral blood supply. It remains unclear whether blood flow in both CCA contributes equally to brain activity. Here, CCA blood flow was evaluated using ultrasonography in 23 patients with cerebrovascular diseases. Resting-state brain activity and cognitive status were also assessed using magnetoencephalography and a cognitive subscale of the Functional Independence Measure, respectively, to explore the relationships between blood flow, functional brain activity, and cognitive status. Our findings indicated that there was an association between blood flow and resting-state brain activity, and between resting-state brain activity and cognitive status. However, blood flow was not significantly associated with cognitive status directly. Furthermore, blood velocity in the right CCA correlated with resting-state brain activity, but not with the resistance index. In contrast, the resistance index in the left CCA correlated with resting-state brain activity, but not with blood velocity. Our findings suggest that hypoperfusion is important in the right CCA, whereas cerebral microcirculation is important in the left CCA for brain activity. Hence, this asymmetry should be considered when designing appropriate therapeutic strategies.Takahiro MatsumotoHideyuki HoshiYoko HirataSayuri IchikawaKeisuke FukasawaTomoyuki GondaJesús PozaVíctor Rodríguez-GonzálezCarlos GómezYoshihito ShigiharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takahiro Matsumoto Hideyuki Hoshi Yoko Hirata Sayuri Ichikawa Keisuke Fukasawa Tomoyuki Gonda Jesús Poza Víctor Rodríguez-González Carlos Gómez Yoshihito Shigihara The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
description	Abstract Cerebral hypoperfusion impairs brain activity and leads to cognitive impairment. Left and right common carotid arteries (CCA) are the major source of cerebral blood supply. It remains unclear whether blood flow in both CCA contributes equally to brain activity. Here, CCA blood flow was evaluated using ultrasonography in 23 patients with cerebrovascular diseases. Resting-state brain activity and cognitive status were also assessed using magnetoencephalography and a cognitive subscale of the Functional Independence Measure, respectively, to explore the relationships between blood flow, functional brain activity, and cognitive status. Our findings indicated that there was an association between blood flow and resting-state brain activity, and between resting-state brain activity and cognitive status. However, blood flow was not significantly associated with cognitive status directly. Furthermore, blood velocity in the right CCA correlated with resting-state brain activity, but not with the resistance index. In contrast, the resistance index in the left CCA correlated with resting-state brain activity, but not with blood velocity. Our findings suggest that hypoperfusion is important in the right CCA, whereas cerebral microcirculation is important in the left CCA for brain activity. Hence, this asymmetry should be considered when designing appropriate therapeutic strategies.
format	article
author	Takahiro Matsumoto Hideyuki Hoshi Yoko Hirata Sayuri Ichikawa Keisuke Fukasawa Tomoyuki Gonda Jesús Poza Víctor Rodríguez-González Carlos Gómez Yoshihito Shigihara
author_facet	Takahiro Matsumoto Hideyuki Hoshi Yoko Hirata Sayuri Ichikawa Keisuke Fukasawa Tomoyuki Gonda Jesús Poza Víctor Rodríguez-González Carlos Gómez Yoshihito Shigihara
author_sort	Takahiro Matsumoto
title	The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
title_short	The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
title_full	The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
title_fullStr	The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
title_full_unstemmed	The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
title_sort	association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b24f3928ef34fe79a9065ef17d2cec0
work_keys_str_mv	AT takahiromatsumoto theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT hideyukihoshi theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT yokohirata theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT sayuriichikawa theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT keisukefukasawa theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT tomoyukigonda theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT jesuspoza theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT victorrodriguezgonzalez theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT carlosgomez theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT yoshihitoshigihara theassociationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT takahiromatsumoto associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT hideyukihoshi associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT yokohirata associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT sayuriichikawa associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT keisukefukasawa associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT tomoyukigonda associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT jesuspoza associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT victorrodriguezgonzalez associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT carlosgomez associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases AT yoshihitoshigihara associationbetweencarotidbloodflowandrestingstatebrainactivityinpatientswithcerebrovasculardiseases
_version_	1718384887512170496

The association between carotid blood flow and resting-state brain activity in patients with cerebrovascular diseases

Ejemplares similares