Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue

Abstract The ability to characterize the combined structural, functional, and thermal properties of biophysically dynamic samples is needed to address critical questions related to tissue structure, physiological dynamics, and disease progression. Towards this, we have developed an imaging platform...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Wilson R. Adams, Brian Mehl, Eric Lieser, Manqing Wang, Shane Patton, Graham A. Throckmorton, J. Logan Jenkins, Jeremy B. Ford, Rekha Gautam, Jeff Brooker, E. Duco Jansen, Anita Mahadevan-Jansen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b25eda4f11d4468a34fa298c48ab4dc
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1b25eda4f11d4468a34fa298c48ab4dc
record_format	dspace
spelling	oai:doaj.org-article:1b25eda4f11d4468a34fa298c48ab4dc2021-12-02T15:51:16ZMulti-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue10.1038/s41598-021-86774-22045-2322https://doaj.org/article/1b25eda4f11d4468a34fa298c48ab4dc2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86774-2https://doaj.org/toc/2045-2322Abstract The ability to characterize the combined structural, functional, and thermal properties of biophysically dynamic samples is needed to address critical questions related to tissue structure, physiological dynamics, and disease progression. Towards this, we have developed an imaging platform that enables multiple nonlinear imaging modalities to be combined with thermal imaging on a common sample. Here we demonstrate label-free multimodal imaging of live cells, excised tissues, and live rodent brain models. While potential applications of this technology are wide-ranging, we expect it to be especially useful in addressing biomedical research questions aimed at the biomolecular and biophysical properties of tissue and their physiology.Wilson R. AdamsBrian MehlEric LieserManqing WangShane PattonGraham A. ThrockmortonJ. Logan JenkinsJeremy B. FordRekha GautamJeff BrookerE. Duco JansenAnita Mahadevan-JansenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wilson R. Adams Brian Mehl Eric Lieser Manqing Wang Shane Patton Graham A. Throckmorton J. Logan Jenkins Jeremy B. Ford Rekha Gautam Jeff Brooker E. Duco Jansen Anita Mahadevan-Jansen Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
description	Abstract The ability to characterize the combined structural, functional, and thermal properties of biophysically dynamic samples is needed to address critical questions related to tissue structure, physiological dynamics, and disease progression. Towards this, we have developed an imaging platform that enables multiple nonlinear imaging modalities to be combined with thermal imaging on a common sample. Here we demonstrate label-free multimodal imaging of live cells, excised tissues, and live rodent brain models. While potential applications of this technology are wide-ranging, we expect it to be especially useful in addressing biomedical research questions aimed at the biomolecular and biophysical properties of tissue and their physiology.
format	article
author	Wilson R. Adams Brian Mehl Eric Lieser Manqing Wang Shane Patton Graham A. Throckmorton J. Logan Jenkins Jeremy B. Ford Rekha Gautam Jeff Brooker E. Duco Jansen Anita Mahadevan-Jansen
author_facet	Wilson R. Adams Brian Mehl Eric Lieser Manqing Wang Shane Patton Graham A. Throckmorton J. Logan Jenkins Jeremy B. Ford Rekha Gautam Jeff Brooker E. Duco Jansen Anita Mahadevan-Jansen
author_sort	Wilson R. Adams
title	Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
title_short	Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
title_full	Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
title_fullStr	Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
title_full_unstemmed	Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
title_sort	multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b25eda4f11d4468a34fa298c48ab4dc
work_keys_str_mv	AT wilsonradams multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT brianmehl multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT ericlieser multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT manqingwang multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT shanepatton multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT grahamathrockmorton multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT jloganjenkins multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT jeremybford multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT rekhagautam multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT jeffbrooker multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT educojansen multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue AT anitamahadevanjansen multimodalnonlinearopticalandthermalimagingplatformforlabelfreecharacterizationofbiologicaltissue
_version_	1718385616099475456

Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue

Ejemplares similares