Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex

Abstract Genetic evidence indicates that haploinsufficiency of ARID1B causes intellectual disability (ID) and autism spectrum disorder (ASD), but the neural function of ARID1B is largely unknown. Using both conditional and global Arid1b knockout mouse strains, we examined the role of ARID1B in neura...

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Autores principales:	Jeffrey J. Moffat, Eui-Man Jung, Minhan Ka, Byeong Tak Jeon, Hyunkyoung Lee, Woo-Yang Kim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b26474e510c494a973e8f34bf106e31
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spelling	oai:doaj.org-article:1b26474e510c494a973e8f34bf106e312021-12-02T14:03:45ZDifferential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex10.1038/s41598-021-82974-y2045-2322https://doaj.org/article/1b26474e510c494a973e8f34bf106e312021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-82974-yhttps://doaj.org/toc/2045-2322Abstract Genetic evidence indicates that haploinsufficiency of ARID1B causes intellectual disability (ID) and autism spectrum disorder (ASD), but the neural function of ARID1B is largely unknown. Using both conditional and global Arid1b knockout mouse strains, we examined the role of ARID1B in neural progenitors. We detected an overall decrease in the proliferation of cortical and ventral neural progenitors following homozygous deletion of Arid1b, as well as altered cell cycle regulation and increased cell death. Each of these phenotypes was more pronounced in ventral neural progenitors. Furthermore, we observed decreased nuclear localization of β-catenin in Arid1b-deficient neurons. Conditional homozygous deletion of Arid1b in ventral neural progenitors led to pronounced ID- and ASD-like behaviors in mice, whereas the deletion in cortical neural progenitors resulted in minor cognitive deficits. This study suggests an essential role for ARID1B in forebrain neurogenesis and clarifies its more pronounced role in inhibitory neural progenitors. Our findings also provide insights into the pathogenesis of ID and ASD.Jeffrey J. MoffatEui-Man JungMinhan KaByeong Tak JeonHyunkyoung LeeWoo-Yang KimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jeffrey J. Moffat Eui-Man Jung Minhan Ka Byeong Tak Jeon Hyunkyoung Lee Woo-Yang Kim Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex
description	Abstract Genetic evidence indicates that haploinsufficiency of ARID1B causes intellectual disability (ID) and autism spectrum disorder (ASD), but the neural function of ARID1B is largely unknown. Using both conditional and global Arid1b knockout mouse strains, we examined the role of ARID1B in neural progenitors. We detected an overall decrease in the proliferation of cortical and ventral neural progenitors following homozygous deletion of Arid1b, as well as altered cell cycle regulation and increased cell death. Each of these phenotypes was more pronounced in ventral neural progenitors. Furthermore, we observed decreased nuclear localization of β-catenin in Arid1b-deficient neurons. Conditional homozygous deletion of Arid1b in ventral neural progenitors led to pronounced ID- and ASD-like behaviors in mice, whereas the deletion in cortical neural progenitors resulted in minor cognitive deficits. This study suggests an essential role for ARID1B in forebrain neurogenesis and clarifies its more pronounced role in inhibitory neural progenitors. Our findings also provide insights into the pathogenesis of ID and ASD.
format	article
author	Jeffrey J. Moffat Eui-Man Jung Minhan Ka Byeong Tak Jeon Hyunkyoung Lee Woo-Yang Kim
author_facet	Jeffrey J. Moffat Eui-Man Jung Minhan Ka Byeong Tak Jeon Hyunkyoung Lee Woo-Yang Kim
author_sort	Jeffrey J. Moffat
title	Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex
title_short	Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex
title_full	Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex
title_fullStr	Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex
title_full_unstemmed	Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex
title_sort	differential roles of arid1b in excitatory and inhibitory neural progenitors in the developing cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b26474e510c494a973e8f34bf106e31
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Differential roles of ARID1B in excitatory and inhibitory neural progenitors in the developing cortex

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