Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study

Abstract Non-alcoholic fatty liver disease (NAFLD) is a chronic disease with several degrees of histological features which may progress to cirrhosis. Obesity is an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery has been associated with NAFLD re...

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Autores principales:	Felipe David Mendonça Chaim, Lívia Bitencourt Pascoal, Fábio Henrique Mendonça Chaim, Bruna Biazon Palma, Tiago Andrade Damázio, Larissa Bastos Eloy da Costa, Rita Carvalho, Everton Cazzo, Martinho Antônio Gestic, Murillo Pimentel Utrini, Marciane Milanski, Elinton Adami Chaim, Raquel Franco Leal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b269e60e30f435c92e6cb55e862cc74
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spelling	oai:doaj.org-article:1b269e60e30f435c92e6cb55e862cc742021-12-02T14:58:32ZHistological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study10.1038/s41598-020-65556-22045-2322https://doaj.org/article/1b269e60e30f435c92e6cb55e862cc742020-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-65556-2https://doaj.org/toc/2045-2322Abstract Non-alcoholic fatty liver disease (NAFLD) is a chronic disease with several degrees of histological features which may progress to cirrhosis. Obesity is an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery has been associated with NAFLD regression in severely obese patients. However, few longitudinal histological studies support this finding. Therefore, firstly, a retrospective study was performed including clinical and histological data of 895 obese patients who underwent bariatric surgery. In addition, histological analyses of 30 patient’s liver biopsies were evaluated at two timepoints (T1 and T2). The retrospective analysis of the total number of patients revealed that the average body mass index (BMI) was 35.91 ± 2.81 kg/m2. The liver biopsies during bariatric surgery showed that 53.52% did not present NAFLD, 30.16% had NASH, 15.98% isolated steatosis and 0.34% liver cirrhosis. The median BMI of the longitudinal cohort decreased from 37.9 ± 2.21 kg/m2 at the time of bariatric surgery (T1) to 25.69 ± 3.79 kg/m2 after 21 ± 22 months after the procedure (T2). The prevalence of NAFLD in T1 was 50%, and 16.67% in T2. The histological area of collagen fiber was lower in T2 compared to T1 (p = 0.0152) in the majority of patients, which was also illustrated by immunohistochemistry for Kupffer cell and myofibroblast formation markers. These findings confirmed the NAFLD regression after bariatric surgery and, for the first time, showed the amelioration of these features using more accurate histopathological techniques.Felipe David Mendonça ChaimLívia Bitencourt PascoalFábio Henrique Mendonça ChaimBruna Biazon PalmaTiago Andrade DamázioLarissa Bastos Eloy da CostaRita CarvalhoEverton CazzoMartinho Antônio GesticMurillo Pimentel UtriniMarciane MilanskiElinton Adami ChaimRaquel Franco LealNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Felipe David Mendonça Chaim Lívia Bitencourt Pascoal Fábio Henrique Mendonça Chaim Bruna Biazon Palma Tiago Andrade Damázio Larissa Bastos Eloy da Costa Rita Carvalho Everton Cazzo Martinho Antônio Gestic Murillo Pimentel Utrini Marciane Milanski Elinton Adami Chaim Raquel Franco Leal Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study
description	Abstract Non-alcoholic fatty liver disease (NAFLD) is a chronic disease with several degrees of histological features which may progress to cirrhosis. Obesity is an important risk factor and although NAFLD has no specific pharmacological treatment, bariatric surgery has been associated with NAFLD regression in severely obese patients. However, few longitudinal histological studies support this finding. Therefore, firstly, a retrospective study was performed including clinical and histological data of 895 obese patients who underwent bariatric surgery. In addition, histological analyses of 30 patient’s liver biopsies were evaluated at two timepoints (T1 and T2). The retrospective analysis of the total number of patients revealed that the average body mass index (BMI) was 35.91 ± 2.81 kg/m2. The liver biopsies during bariatric surgery showed that 53.52% did not present NAFLD, 30.16% had NASH, 15.98% isolated steatosis and 0.34% liver cirrhosis. The median BMI of the longitudinal cohort decreased from 37.9 ± 2.21 kg/m2 at the time of bariatric surgery (T1) to 25.69 ± 3.79 kg/m2 after 21 ± 22 months after the procedure (T2). The prevalence of NAFLD in T1 was 50%, and 16.67% in T2. The histological area of collagen fiber was lower in T2 compared to T1 (p = 0.0152) in the majority of patients, which was also illustrated by immunohistochemistry for Kupffer cell and myofibroblast formation markers. These findings confirmed the NAFLD regression after bariatric surgery and, for the first time, showed the amelioration of these features using more accurate histopathological techniques.
format	article
author	Felipe David Mendonça Chaim Lívia Bitencourt Pascoal Fábio Henrique Mendonça Chaim Bruna Biazon Palma Tiago Andrade Damázio Larissa Bastos Eloy da Costa Rita Carvalho Everton Cazzo Martinho Antônio Gestic Murillo Pimentel Utrini Marciane Milanski Elinton Adami Chaim Raquel Franco Leal
author_facet	Felipe David Mendonça Chaim Lívia Bitencourt Pascoal Fábio Henrique Mendonça Chaim Bruna Biazon Palma Tiago Andrade Damázio Larissa Bastos Eloy da Costa Rita Carvalho Everton Cazzo Martinho Antônio Gestic Murillo Pimentel Utrini Marciane Milanski Elinton Adami Chaim Raquel Franco Leal
author_sort	Felipe David Mendonça Chaim
title	Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study
title_short	Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study
title_full	Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study
title_fullStr	Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study
title_full_unstemmed	Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study
title_sort	histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1b269e60e30f435c92e6cb55e862cc74
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Histological grading evaluation of non-alcoholic fatty liver disease after bariatric surgery: a retrospective and longitudinal observational cohort study

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