Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives

Diet is one of the most important factors regulating and influencing the composition of our gut microbiome, but the specific effects of commonly used antimicrobial agents i.e., food preservatives present within foods, are not completely understood. In this study, we examined the effect of the three...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ravinder Nagpal, Nagaraju Indugu, Prashant Singh
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	benzoate food additives food preservation intestine microbiota microflora Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1b28d1c5d7484adca2fb1a1c5266038e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1b28d1c5d7484adca2fb1a1c5266038e
record_format	dspace
spelling	oai:doaj.org-article:1b28d1c5d7484adca2fb1a1c5266038e2021-11-25T18:25:01ZDistinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives10.3390/microorganisms91123112076-2607https://doaj.org/article/1b28d1c5d7484adca2fb1a1c5266038e2021-11-01T00:00:00Zhttps://www.mdpi.com/2076-2607/9/11/2311https://doaj.org/toc/2076-2607Diet is one of the most important factors regulating and influencing the composition of our gut microbiome, but the specific effects of commonly used antimicrobial agents i.e., food preservatives present within foods, are not completely understood. In this study, we examined the effect of the three widely used food-grade preservatives i.e., benzoic acid, potassium sorbate, and sodium nitrite, in recommended levels, on the gut microbiota diversity and composition in a mouse model. The analysis of β-diversity reveals distinct signatures of the gut microbiota between mice consuming different preservatives. Further analyses of α-diversity indices also show that the three preservatives induce specific patterns of microbial diversity, with diversity being lowest in mice consuming potassium sorbate. In terms of bacterial abundance, each of the three preservatives demonstrated unique microbial signatures, mainly affecting the proportions of bacterial taxa belonging to <i>Bacteroidetes</i>, <i>Verrucomicrobia</i>, and <i>Proteobacteria</i>. Specifically, we find the increased proportion of <i>Bacteroides</i>, <i>Blautia</i>, <i>Ruminococcus</i>, <i>Oscillospira</i>, and <i>Dorea</i> in mice fed with benzoate; increased abundance of <i>Firmicutes</i>, <i>Turicibacter</i>, and <i>Alkaliphilus</i> by sodium nitrate; and increased proportion of <i>Parabacteroides</i> and <i>Adlercreutzia</i> by potassium sorbate. The findings improve our understanding of how food-grade preservatives may influence the gut microbiota composition and diversity and should facilitate prospective studies investigating diet-microbiome interactions in relation to intestinal and metabolic health.Ravinder NagpalNagaraju InduguPrashant SinghMDPI AGarticlebenzoatefood additivesfood preservationintestinemicrobiotamicrofloraBiology (General)QH301-705.5ENMicroorganisms, Vol 9, Iss 2311, p 2311 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	benzoate food additives food preservation intestine microbiota microflora Biology (General) QH301-705.5
spellingShingle	benzoate food additives food preservation intestine microbiota microflora Biology (General) QH301-705.5 Ravinder Nagpal Nagaraju Indugu Prashant Singh Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives
description	Diet is one of the most important factors regulating and influencing the composition of our gut microbiome, but the specific effects of commonly used antimicrobial agents i.e., food preservatives present within foods, are not completely understood. In this study, we examined the effect of the three widely used food-grade preservatives i.e., benzoic acid, potassium sorbate, and sodium nitrite, in recommended levels, on the gut microbiota diversity and composition in a mouse model. The analysis of β-diversity reveals distinct signatures of the gut microbiota between mice consuming different preservatives. Further analyses of α-diversity indices also show that the three preservatives induce specific patterns of microbial diversity, with diversity being lowest in mice consuming potassium sorbate. In terms of bacterial abundance, each of the three preservatives demonstrated unique microbial signatures, mainly affecting the proportions of bacterial taxa belonging to <i>Bacteroidetes</i>, <i>Verrucomicrobia</i>, and <i>Proteobacteria</i>. Specifically, we find the increased proportion of <i>Bacteroides</i>, <i>Blautia</i>, <i>Ruminococcus</i>, <i>Oscillospira</i>, and <i>Dorea</i> in mice fed with benzoate; increased abundance of <i>Firmicutes</i>, <i>Turicibacter</i>, and <i>Alkaliphilus</i> by sodium nitrate; and increased proportion of <i>Parabacteroides</i> and <i>Adlercreutzia</i> by potassium sorbate. The findings improve our understanding of how food-grade preservatives may influence the gut microbiota composition and diversity and should facilitate prospective studies investigating diet-microbiome interactions in relation to intestinal and metabolic health.
format	article
author	Ravinder Nagpal Nagaraju Indugu Prashant Singh
author_facet	Ravinder Nagpal Nagaraju Indugu Prashant Singh
author_sort	Ravinder Nagpal
title	Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives
title_short	Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives
title_full	Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives
title_fullStr	Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives
title_full_unstemmed	Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives
title_sort	distinct gut microbiota signatures in mice treated with commonly used food preservatives
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1b28d1c5d7484adca2fb1a1c5266038e
work_keys_str_mv	AT ravindernagpal distinctgutmicrobiotasignaturesinmicetreatedwithcommonlyusedfoodpreservatives AT nagarajuindugu distinctgutmicrobiotasignaturesinmicetreatedwithcommonlyusedfoodpreservatives AT prashantsingh distinctgutmicrobiotasignaturesinmicetreatedwithcommonlyusedfoodpreservatives
_version_	1718411182897889280

Distinct Gut Microbiota Signatures in Mice Treated with Commonly Used Food Preservatives

Ejemplares similares