ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

Multivesicular bodies (MVB) are endosomal compartments that can either fuse with the plasma membrane for the secretion of exosomes, or fuse with the lysosome and be degraded along with their contents. Here, the authors show that ISGylation of the MVB protein TSG101 impairs exosome secretion and acts...

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Autores principales:	Carolina Villarroya-Beltri, Francesc Baixauli, María Mittelbrunn, Irene Fernández-Delgado, Daniel Torralba, Olga Moreno-Gonzalo, Sara Baldanta, Carlos Enrich, Susana Guerra, Francisco Sánchez-Madrid
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b2e7f717e724460ac0843fd8652dd65
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spelling	oai:doaj.org-article:1b2e7f717e724460ac0843fd8652dd652021-12-02T16:49:42ZISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins10.1038/ncomms135882041-1723https://doaj.org/article/1b2e7f717e724460ac0843fd8652dd652016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13588https://doaj.org/toc/2041-1723Multivesicular bodies (MVB) are endosomal compartments that can either fuse with the plasma membrane for the secretion of exosomes, or fuse with the lysosome and be degraded along with their contents. Here, the authors show that ISGylation of the MVB protein TSG101 impairs exosome secretion and acts as a regulator of MVB fate.Carolina Villarroya-BeltriFrancesc BaixauliMaría MittelbrunnIrene Fernández-DelgadoDaniel TorralbaOlga Moreno-GonzaloSara BaldantaCarlos EnrichSusana GuerraFrancisco Sánchez-MadridNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carolina Villarroya-Beltri Francesc Baixauli María Mittelbrunn Irene Fernández-Delgado Daniel Torralba Olga Moreno-Gonzalo Sara Baldanta Carlos Enrich Susana Guerra Francisco Sánchez-Madrid ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
description	Multivesicular bodies (MVB) are endosomal compartments that can either fuse with the plasma membrane for the secretion of exosomes, or fuse with the lysosome and be degraded along with their contents. Here, the authors show that ISGylation of the MVB protein TSG101 impairs exosome secretion and acts as a regulator of MVB fate.
format	article
author	Carolina Villarroya-Beltri Francesc Baixauli María Mittelbrunn Irene Fernández-Delgado Daniel Torralba Olga Moreno-Gonzalo Sara Baldanta Carlos Enrich Susana Guerra Francisco Sánchez-Madrid
author_facet	Carolina Villarroya-Beltri Francesc Baixauli María Mittelbrunn Irene Fernández-Delgado Daniel Torralba Olga Moreno-Gonzalo Sara Baldanta Carlos Enrich Susana Guerra Francisco Sánchez-Madrid
author_sort	Carolina Villarroya-Beltri
title	ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
title_short	ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
title_full	ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
title_fullStr	ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
title_full_unstemmed	ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins
title_sort	isgylation controls exosome secretion by promoting lysosomal degradation of mvb proteins
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/1b2e7f717e724460ac0843fd8652dd65
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ISGylation controls exosome secretion by promoting lysosomal degradation of MVB proteins

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