Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells

Gene expression covariation can be studied by single-cell RNA sequencing. Here the authors analyze intrinsically covarying gene pairs by eliminating the confounding effects in single-cell experiments and observe covariation of proximal genes and miRNA-induced covariation of target mRNAs.

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Autores principales:	Marcel Tarbier, Sebastian D. Mackowiak, João Frade, Silvina Catuara-Solarz, Inna Biryukova, Eleni Gelali, Diego Bárcena Menéndez, Luis Zapata, Stephan Ossowski, Magda Bienko, Caroline J. Gallant, Marc R. Friedländer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b30aeb9e4ad4e72990215030189e092
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spelling	oai:doaj.org-article:1b30aeb9e4ad4e72990215030189e0922021-12-02T15:37:19ZNuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells10.1038/s41467-020-19011-52041-1723https://doaj.org/article/1b30aeb9e4ad4e72990215030189e0922020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19011-5https://doaj.org/toc/2041-1723Gene expression covariation can be studied by single-cell RNA sequencing. Here the authors analyze intrinsically covarying gene pairs by eliminating the confounding effects in single-cell experiments and observe covariation of proximal genes and miRNA-induced covariation of target mRNAs.Marcel TarbierSebastian D. MackowiakJoão FradeSilvina Catuara-SolarzInna BiryukovaEleni GelaliDiego Bárcena MenéndezLuis ZapataStephan OssowskiMagda BienkoCaroline J. GallantMarc R. FriedländerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marcel Tarbier Sebastian D. Mackowiak João Frade Silvina Catuara-Solarz Inna Biryukova Eleni Gelali Diego Bárcena Menéndez Luis Zapata Stephan Ossowski Magda Bienko Caroline J. Gallant Marc R. Friedländer Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
description	Gene expression covariation can be studied by single-cell RNA sequencing. Here the authors analyze intrinsically covarying gene pairs by eliminating the confounding effects in single-cell experiments and observe covariation of proximal genes and miRNA-induced covariation of target mRNAs.
format	article
author	Marcel Tarbier Sebastian D. Mackowiak João Frade Silvina Catuara-Solarz Inna Biryukova Eleni Gelali Diego Bárcena Menéndez Luis Zapata Stephan Ossowski Magda Bienko Caroline J. Gallant Marc R. Friedländer
author_facet	Marcel Tarbier Sebastian D. Mackowiak João Frade Silvina Catuara-Solarz Inna Biryukova Eleni Gelali Diego Bárcena Menéndez Luis Zapata Stephan Ossowski Magda Bienko Caroline J. Gallant Marc R. Friedländer
author_sort	Marcel Tarbier
title	Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
title_short	Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
title_full	Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
title_fullStr	Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
title_full_unstemmed	Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
title_sort	nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1b30aeb9e4ad4e72990215030189e092
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Nuclear gene proximity and protein interactions shape transcript covariations in mammalian single cells

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