Effects of circadian misalignment on sleep in mice

Abstract Circadian rhythms and sleep-wake history determine sleep duration and intensity, and influence subsequent waking. Previous studies have shown that T cycles - light-dark (LD) cycles differing from 24 h - lead to acute changes in the daily amount and distribution of waking and sleep. However,...

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Autores principales:	Sibah Hasan, Russell G. Foster, Vladyslav V. Vyazovskiy, Stuart N. Peirson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Circadian Misalignment NREM Sleep Slow Wave Activity Core Body Temperature Vigilance States Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b3178f8f0a94faa85a910285df92d3d
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spelling	oai:doaj.org-article:1b3178f8f0a94faa85a910285df92d3d2021-12-02T15:08:44ZEffects of circadian misalignment on sleep in mice10.1038/s41598-018-33480-12045-2322https://doaj.org/article/1b3178f8f0a94faa85a910285df92d3d2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-33480-1https://doaj.org/toc/2045-2322Abstract Circadian rhythms and sleep-wake history determine sleep duration and intensity, and influence subsequent waking. Previous studies have shown that T cycles - light-dark (LD) cycles differing from 24 h - lead to acute changes in the daily amount and distribution of waking and sleep. However, little is known about the long-term effects of T cycles. Here we performed continuous 10 day recording of electroencephalography (EEG), locomotor activity and core body temperature in C57BL/6 mice under a T20 cycle, to investigate spontaneous sleep and waking at baseline compared with when the circadian clock was misaligned and then re-aligned with respect to the external LD cycle. We found that the rhythmic distribution of sleep was abolished during misalignment, while the time course of EEG slow wave activity (1–4 Hz) was inverted compared to baseline. Although the typical light-dark distribution of NREM sleep was re-instated when animals were re-aligned, slow wave activity during NREM sleep showed an atypical increase in the dark phase, suggesting a long-term effect of T cycles on sleep intensity. Our data show that circadian misalignment results in previously uncharacterised long-term effects on sleep, which may have important consequences for behaviour.Sibah HasanRussell G. FosterVladyslav V. VyazovskiyStuart N. PeirsonNature PortfolioarticleCircadian MisalignmentNREM SleepSlow Wave ActivityCore Body TemperatureVigilance StatesMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Circadian Misalignment NREM Sleep Slow Wave Activity Core Body Temperature Vigilance States Medicine R Science Q
spellingShingle	Circadian Misalignment NREM Sleep Slow Wave Activity Core Body Temperature Vigilance States Medicine R Science Q Sibah Hasan Russell G. Foster Vladyslav V. Vyazovskiy Stuart N. Peirson Effects of circadian misalignment on sleep in mice
description	Abstract Circadian rhythms and sleep-wake history determine sleep duration and intensity, and influence subsequent waking. Previous studies have shown that T cycles - light-dark (LD) cycles differing from 24 h - lead to acute changes in the daily amount and distribution of waking and sleep. However, little is known about the long-term effects of T cycles. Here we performed continuous 10 day recording of electroencephalography (EEG), locomotor activity and core body temperature in C57BL/6 mice under a T20 cycle, to investigate spontaneous sleep and waking at baseline compared with when the circadian clock was misaligned and then re-aligned with respect to the external LD cycle. We found that the rhythmic distribution of sleep was abolished during misalignment, while the time course of EEG slow wave activity (1–4 Hz) was inverted compared to baseline. Although the typical light-dark distribution of NREM sleep was re-instated when animals were re-aligned, slow wave activity during NREM sleep showed an atypical increase in the dark phase, suggesting a long-term effect of T cycles on sleep intensity. Our data show that circadian misalignment results in previously uncharacterised long-term effects on sleep, which may have important consequences for behaviour.
format	article
author	Sibah Hasan Russell G. Foster Vladyslav V. Vyazovskiy Stuart N. Peirson
author_facet	Sibah Hasan Russell G. Foster Vladyslav V. Vyazovskiy Stuart N. Peirson
author_sort	Sibah Hasan
title	Effects of circadian misalignment on sleep in mice
title_short	Effects of circadian misalignment on sleep in mice
title_full	Effects of circadian misalignment on sleep in mice
title_fullStr	Effects of circadian misalignment on sleep in mice
title_full_unstemmed	Effects of circadian misalignment on sleep in mice
title_sort	effects of circadian misalignment on sleep in mice
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/1b3178f8f0a94faa85a910285df92d3d
work_keys_str_mv	AT sibahhasan effectsofcircadianmisalignmentonsleepinmice AT russellgfoster effectsofcircadianmisalignmentonsleepinmice AT vladyslavvvyazovskiy effectsofcircadianmisalignmentonsleepinmice AT stuartnpeirson effectsofcircadianmisalignmentonsleepinmice
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Effects of circadian misalignment on sleep in mice

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