A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.

<h4>Unlabelled</h4>Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life. Previously, we reported the successful use of a novel brain-computer interface (BCI) training system in improving symptoms of attention def...

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Autores principales:	Tih-Shih Lee, Siau Juinn Alexa Goh, Shin Yi Quek, Rachel Phillips, Cuntai Guan, Yin Bun Cheung, Lei Feng, Stephanie Sze Wei Teng, Chuan Chu Wang, Zheng Yang Chin, Haihong Zhang, Tze Pin Ng, Jimmy Lee, Richard Keefe, K Ranga Rama Krishnan
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b36374d72524b9786e2666870293271
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spelling	oai:doaj.org-article:1b36374d72524b9786e26668702932712021-11-18T08:45:53ZA brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.1932-620310.1371/journal.pone.0079419https://doaj.org/article/1b36374d72524b9786e26668702932712013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24260218/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Unlabelled</h4>Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life. Previously, we reported the successful use of a novel brain-computer interface (BCI) training system in improving symptoms of attention deficit hyperactivity disorder. Here, we examine the feasibility of the BCI system with a new game that incorporates memory training in improving memory and attention in a pilot sample of healthy elderly. This study investigates the safety, usability and acceptability of our BCI system to elderly, and obtains an efficacy estimate to warrant a phase III trial. Thirty-one healthy elderly were randomized into intervention (n = 15) and waitlist control arms (n = 16). Intervention consisted of an 8-week training comprising 24 half-hour sessions. A usability and acceptability questionnaire was administered at the end of training. Safety was investigated by querying users about adverse events after every session. Efficacy of the system was measured by the change of total score from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) before and after training. Feedback on the usability and acceptability questionnaire was positive. No adverse events were reported for all participants across all sessions. Though the median difference in the RBANS change scores between arms was not statistically significant, an effect size of 0.6SD was obtained, which reflects potential clinical utility according to Simon's randomized phase II trial design. Pooled data from both arms also showed that the median change in total scores pre and post-training was statistically significant (Mdn = 4.0; p<0.001). Specifically, there were significant improvements in immediate memory (p = 0.038), visuospatial/constructional (p = 0.014), attention (p = 0.039), and delayed memory (p<0.001) scores. Our BCI-based system shows promise in improving memory and attention in healthy elderly, and appears to be safe, user-friendly and acceptable to senior users. Given the efficacy signal, a phase III trial is warranted.<h4>Trial registration</h4>ClinicalTrials.gov NCT01661894.Tih-Shih LeeSiau Juinn Alexa GohShin Yi QuekRachel PhillipsCuntai GuanYin Bun CheungLei FengStephanie Sze Wei TengChuan Chu WangZheng Yang ChinHaihong ZhangTze Pin NgJimmy LeeRichard KeefeK Ranga Rama KrishnanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 11, p e79419 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tih-Shih Lee Siau Juinn Alexa Goh Shin Yi Quek Rachel Phillips Cuntai Guan Yin Bun Cheung Lei Feng Stephanie Sze Wei Teng Chuan Chu Wang Zheng Yang Chin Haihong Zhang Tze Pin Ng Jimmy Lee Richard Keefe K Ranga Rama Krishnan A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.
description	<h4>Unlabelled</h4>Cognitive decline in aging is a pressing issue associated with significant healthcare costs and deterioration in quality of life. Previously, we reported the successful use of a novel brain-computer interface (BCI) training system in improving symptoms of attention deficit hyperactivity disorder. Here, we examine the feasibility of the BCI system with a new game that incorporates memory training in improving memory and attention in a pilot sample of healthy elderly. This study investigates the safety, usability and acceptability of our BCI system to elderly, and obtains an efficacy estimate to warrant a phase III trial. Thirty-one healthy elderly were randomized into intervention (n = 15) and waitlist control arms (n = 16). Intervention consisted of an 8-week training comprising 24 half-hour sessions. A usability and acceptability questionnaire was administered at the end of training. Safety was investigated by querying users about adverse events after every session. Efficacy of the system was measured by the change of total score from the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) before and after training. Feedback on the usability and acceptability questionnaire was positive. No adverse events were reported for all participants across all sessions. Though the median difference in the RBANS change scores between arms was not statistically significant, an effect size of 0.6SD was obtained, which reflects potential clinical utility according to Simon's randomized phase II trial design. Pooled data from both arms also showed that the median change in total scores pre and post-training was statistically significant (Mdn = 4.0; p<0.001). Specifically, there were significant improvements in immediate memory (p = 0.038), visuospatial/constructional (p = 0.014), attention (p = 0.039), and delayed memory (p<0.001) scores. Our BCI-based system shows promise in improving memory and attention in healthy elderly, and appears to be safe, user-friendly and acceptable to senior users. Given the efficacy signal, a phase III trial is warranted.<h4>Trial registration</h4>ClinicalTrials.gov NCT01661894.
format	article
author	Tih-Shih Lee Siau Juinn Alexa Goh Shin Yi Quek Rachel Phillips Cuntai Guan Yin Bun Cheung Lei Feng Stephanie Sze Wei Teng Chuan Chu Wang Zheng Yang Chin Haihong Zhang Tze Pin Ng Jimmy Lee Richard Keefe K Ranga Rama Krishnan
author_facet	Tih-Shih Lee Siau Juinn Alexa Goh Shin Yi Quek Rachel Phillips Cuntai Guan Yin Bun Cheung Lei Feng Stephanie Sze Wei Teng Chuan Chu Wang Zheng Yang Chin Haihong Zhang Tze Pin Ng Jimmy Lee Richard Keefe K Ranga Rama Krishnan
author_sort	Tih-Shih Lee
title	A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.
title_short	A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.
title_full	A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.
title_fullStr	A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.
title_full_unstemmed	A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.
title_sort	brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/1b36374d72524b9786e2666870293271
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A brain-computer interface based cognitive training system for healthy elderly: a randomized control pilot study for usability and preliminary efficacy.

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