Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.

<h4>Background</h4>Transcatheter aortic valve implantation (TAVI) is the standard treatment option for patients with severe aortic stenosis (AS) at intermediate or high surgical risk. Preexisting right bundle branch block (RBBB) is a strong predictor of new pacemaker implantation (PPM) a...

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Autores principales:	Maren Weferling, Christoph Liebetrau, Matthias Renker, Ulrich Fischer-Rasokat, Yeoung-Hoon Choi, Christian W Hamm, Won-Keun Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b3685a2895f40b8b30e6d8de3236376
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spelling	oai:doaj.org-article:1b3685a2895f40b8b30e6d8de32363762021-12-02T20:10:33ZRight bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.1932-620310.1371/journal.pone.0253332https://doaj.org/article/1b3685a2895f40b8b30e6d8de32363762021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253332https://doaj.org/toc/1932-6203<h4>Background</h4>Transcatheter aortic valve implantation (TAVI) is the standard treatment option for patients with severe aortic stenosis (AS) at intermediate or high surgical risk. Preexisting right bundle branch block (RBBB) is a strong predictor of new pacemaker implantation (PPM) after TAVI, and previous data indicate a worse short- and long-term outcome of patients. The aim of this study was to investigate whether preexisting RBBB has an effect on the short- and mid-term outcome of patients undergoing TAVI in a German high-volume TAVI center.<h4>Methods</h4>For the present retrospective analysis, a total of 1,891 patients with native severe AS with successful TAVI without preexisting PPM were included. The primary endpoint was all-cause mortality after 30 days and 12 months. Baseline RBBB was present in 190 (10.1%) of cases.<h4>Results</h4>Patients with preexisting RBBB had a considerably higher rate of new PPM after TAVI compared with patients without RBBB (87/190 [45.8%] vs. 219/1,701 [12.9%]; p<0.001). RBBB had no impact on all-cause mortality at 30 days (2.1% vs. 2.7%; p = 0.625) and at 12 months (14.4% vs. 13.6%; p = 0.765). Further stratification according to the presence of new PPM showed a difference in mid-term survival rates between the four groups, with the worst outcome for patients without RBBB and new PPM (log rank p = 0.024). However, no difference in mid-term cardiovascular survival was found.<h4>Conclusion</h4>Preexisting RBBB is a common finding in patients with severe AS undergoing TAVI and is associated with considerably higher PPM rates but not with worse short- and mid-term outcome.Maren WeferlingChristoph LiebetrauMatthias RenkerUlrich Fischer-RasokatYeoung-Hoon ChoiChristian W HammWon-Keun KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0253332 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maren Weferling Christoph Liebetrau Matthias Renker Ulrich Fischer-Rasokat Yeoung-Hoon Choi Christian W Hamm Won-Keun Kim Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.
description	<h4>Background</h4>Transcatheter aortic valve implantation (TAVI) is the standard treatment option for patients with severe aortic stenosis (AS) at intermediate or high surgical risk. Preexisting right bundle branch block (RBBB) is a strong predictor of new pacemaker implantation (PPM) after TAVI, and previous data indicate a worse short- and long-term outcome of patients. The aim of this study was to investigate whether preexisting RBBB has an effect on the short- and mid-term outcome of patients undergoing TAVI in a German high-volume TAVI center.<h4>Methods</h4>For the present retrospective analysis, a total of 1,891 patients with native severe AS with successful TAVI without preexisting PPM were included. The primary endpoint was all-cause mortality after 30 days and 12 months. Baseline RBBB was present in 190 (10.1%) of cases.<h4>Results</h4>Patients with preexisting RBBB had a considerably higher rate of new PPM after TAVI compared with patients without RBBB (87/190 [45.8%] vs. 219/1,701 [12.9%]; p<0.001). RBBB had no impact on all-cause mortality at 30 days (2.1% vs. 2.7%; p = 0.625) and at 12 months (14.4% vs. 13.6%; p = 0.765). Further stratification according to the presence of new PPM showed a difference in mid-term survival rates between the four groups, with the worst outcome for patients without RBBB and new PPM (log rank p = 0.024). However, no difference in mid-term cardiovascular survival was found.<h4>Conclusion</h4>Preexisting RBBB is a common finding in patients with severe AS undergoing TAVI and is associated with considerably higher PPM rates but not with worse short- and mid-term outcome.
format	article
author	Maren Weferling Christoph Liebetrau Matthias Renker Ulrich Fischer-Rasokat Yeoung-Hoon Choi Christian W Hamm Won-Keun Kim
author_facet	Maren Weferling Christoph Liebetrau Matthias Renker Ulrich Fischer-Rasokat Yeoung-Hoon Choi Christian W Hamm Won-Keun Kim
author_sort	Maren Weferling
title	Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.
title_short	Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.
title_full	Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.
title_fullStr	Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.
title_full_unstemmed	Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.
title_sort	right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1b3685a2895f40b8b30e6d8de3236376
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Right bundle branch block is not associated with worse short- and mid-term outcome after transcatheter aortic valve implantation.

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