Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.

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Autores principales: Laura A. Laviolette, Julien Mermoud, Isabel A. Calvo, Nicholas Olson, Myriam Boukhali, Ortrud K. Steinlein, Elisabeth Roider, Elke C. Sattler, Dachuan Huang, Bin Tean Teh, Mo Motamedi, Wilhelm Haas, Othon Iliopoulos
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/1b380633bddc4eeeab34a8e2fe00f00a
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spelling oai:doaj.org-article:1b380633bddc4eeeab34a8e2fe00f00a2021-12-02T17:06:08ZNegative regulation of EGFR signalling by the human folliculin tumour suppressor protein10.1038/ncomms158662041-1723https://doaj.org/article/1b380633bddc4eeeab34a8e2fe00f00a2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15866https://doaj.org/toc/2041-1723Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.Laura A. LavioletteJulien MermoudIsabel A. CalvoNicholas OlsonMyriam BoukhaliOrtrud K. SteinleinElisabeth RoiderElke C. SattlerDachuan HuangBin Tean TehMo MotamediWilhelm HaasOthon IliopoulosNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Laura A. Laviolette
Julien Mermoud
Isabel A. Calvo
Nicholas Olson
Myriam Boukhali
Ortrud K. Steinlein
Elisabeth Roider
Elke C. Sattler
Dachuan Huang
Bin Tean Teh
Mo Motamedi
Wilhelm Haas
Othon Iliopoulos
Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
description Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.
format article
author Laura A. Laviolette
Julien Mermoud
Isabel A. Calvo
Nicholas Olson
Myriam Boukhali
Ortrud K. Steinlein
Elisabeth Roider
Elke C. Sattler
Dachuan Huang
Bin Tean Teh
Mo Motamedi
Wilhelm Haas
Othon Iliopoulos
author_facet Laura A. Laviolette
Julien Mermoud
Isabel A. Calvo
Nicholas Olson
Myriam Boukhali
Ortrud K. Steinlein
Elisabeth Roider
Elke C. Sattler
Dachuan Huang
Bin Tean Teh
Mo Motamedi
Wilhelm Haas
Othon Iliopoulos
author_sort Laura A. Laviolette
title Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_short Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_full Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_fullStr Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_full_unstemmed Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein
title_sort negative regulation of egfr signalling by the human folliculin tumour suppressor protein
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/1b380633bddc4eeeab34a8e2fe00f00a
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