Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Negative regulation of EGFR signalling by the human folliculin tumour suppressor protein

Folliculin is a known tumour suppressor but the molecular mechanisms behind this function are unclear. Here the authors show that Folliculin regulates EGFR signalling by modulating its Rab7a-dependent trafficking.

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Auteurs principaux: Laura A. Laviolette, Julien Mermoud, Isabel A. Calvo, Nicholas Olson, Myriam Boukhali, Ortrud K. Steinlein, Elisabeth Roider, Elke C. Sattler, Dachuan Huang, Bin Tean Teh, Mo Motamedi, Wilhelm Haas, Othon Iliopoulos
Format: article
Langue:EN
Publié: Nature Portfolio 2017
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Science
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Accès en ligne:https://doaj.org/article/1b380633bddc4eeeab34a8e2fe00f00a
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Internet

https://doaj.org/article/1b380633bddc4eeeab34a8e2fe00f00a

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