Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression
Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells.
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Nature Portfolio
2020
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oai:doaj.org-article:1b3e75d138fe4626bae55cdc8321e3d12021-12-02T18:37:29ZGlioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression10.1038/s41467-020-18569-42041-1723https://doaj.org/article/1b3e75d138fe4626bae55cdc8321e3d12020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18569-4https://doaj.org/toc/2041-1723Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells.Astrid De BoeckBo Young AhnCharlotte D’MelloXueqing LunShyam V. MenonMana M. AlshehriFrank SzulzewskyYaoqing ShenLubaba KhanNgoc Ha DangElliott ReichardtKimberly-Ann GoringJennifer KingCameron J. GrisdaleNatalie GrinshteinDolores HambardzumyanKarlyne M. ReillyMichael D. BloughJ. Gregory CairncrossV. Wee YongMarco A. MarraSteven J. M. JonesDavid R. KaplanKathy D. McCoyEric C. HollandPinaki BoseJennifer A. ChanStephen M. RobbinsDonna L. SengerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-24 (2020) |
| institution |
DOAJ |
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DOAJ |
| language |
EN |
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Science Q |
| spellingShingle |
Science Q Astrid De Boeck Bo Young Ahn Charlotte D’Mello Xueqing Lun Shyam V. Menon Mana M. Alshehri Frank Szulzewsky Yaoqing Shen Lubaba Khan Ngoc Ha Dang Elliott Reichardt Kimberly-Ann Goring Jennifer King Cameron J. Grisdale Natalie Grinshtein Dolores Hambardzumyan Karlyne M. Reilly Michael D. Blough J. Gregory Cairncross V. Wee Yong Marco A. Marra Steven J. M. Jones David R. Kaplan Kathy D. McCoy Eric C. Holland Pinaki Bose Jennifer A. Chan Stephen M. Robbins Donna L. Senger Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
| description |
Elevated levels of interleukin-33 have been associated with poor prognosis in patients with glioma. Here the authors show that glioma-derived IL-33 modulates a pro-tumorigenic immune microenvironment by activating resident and recruiting peripheral innate immune cells. |
| format |
article |
| author |
Astrid De Boeck Bo Young Ahn Charlotte D’Mello Xueqing Lun Shyam V. Menon Mana M. Alshehri Frank Szulzewsky Yaoqing Shen Lubaba Khan Ngoc Ha Dang Elliott Reichardt Kimberly-Ann Goring Jennifer King Cameron J. Grisdale Natalie Grinshtein Dolores Hambardzumyan Karlyne M. Reilly Michael D. Blough J. Gregory Cairncross V. Wee Yong Marco A. Marra Steven J. M. Jones David R. Kaplan Kathy D. McCoy Eric C. Holland Pinaki Bose Jennifer A. Chan Stephen M. Robbins Donna L. Senger |
| author_facet |
Astrid De Boeck Bo Young Ahn Charlotte D’Mello Xueqing Lun Shyam V. Menon Mana M. Alshehri Frank Szulzewsky Yaoqing Shen Lubaba Khan Ngoc Ha Dang Elliott Reichardt Kimberly-Ann Goring Jennifer King Cameron J. Grisdale Natalie Grinshtein Dolores Hambardzumyan Karlyne M. Reilly Michael D. Blough J. Gregory Cairncross V. Wee Yong Marco A. Marra Steven J. M. Jones David R. Kaplan Kathy D. McCoy Eric C. Holland Pinaki Bose Jennifer A. Chan Stephen M. Robbins Donna L. Senger |
| author_sort |
Astrid De Boeck |
| title |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
| title_short |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
| title_full |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
| title_fullStr |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
| title_full_unstemmed |
Glioma-derived IL-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
| title_sort |
glioma-derived il-33 orchestrates an inflammatory brain tumor microenvironment that accelerates glioma progression |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/1b3e75d138fe4626bae55cdc8321e3d1 |
| work_keys_str_mv |
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