Coherent theta activity in the medial and orbital frontal cortices encodes reward value

This study examined how the medial frontal (MFC) and orbital frontal (OFC) cortices process reward information. We simultaneously recorded local field potentials in the two areas as rats consumed liquid sucrose rewards. Both areas exhibited a 4–8 Hz ‘theta’ rhythm that was phase-locked to the lick c...

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Autores principales:	Linda M Amarante, Mark Laubach
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	prefrontal reward consumption MPFC MOFC sucrose Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/1b404aaefd2a43c0bd523405ca735b74
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spelling	oai:doaj.org-article:1b404aaefd2a43c0bd523405ca735b742021-11-24T12:14:47ZCoherent theta activity in the medial and orbital frontal cortices encodes reward value10.7554/eLife.633722050-084Xe63372https://doaj.org/article/1b404aaefd2a43c0bd523405ca735b742021-09-01T00:00:00Zhttps://elifesciences.org/articles/63372https://doaj.org/toc/2050-084XThis study examined how the medial frontal (MFC) and orbital frontal (OFC) cortices process reward information. We simultaneously recorded local field potentials in the two areas as rats consumed liquid sucrose rewards. Both areas exhibited a 4–8 Hz ‘theta’ rhythm that was phase-locked to the lick cycle. The rhythm tracked shifts in sucrose concentrations and fluid volumes, demonstrating that it is sensitive to differences in reward magnitude. The coupling between the rhythm and licking was stronger in MFC than OFC and varied with response vigor and absolute reward value in the MFC. Spectral analysis revealed zero-lag coherence between the cortical areas, and found evidence for a directionality of the rhythm, with MFC leading OFC. Our findings suggest that consummatory behavior generates simultaneous theta range activity in the MFC and OFC that encodes the value of consumed fluids, with the MFC having a top-down role in the control of consumption.Linda M AmaranteMark LaubacheLife Sciences Publications LtdarticleprefrontalrewardconsumptionMPFCMOFCsucroseMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prefrontal reward consumption MPFC MOFC sucrose Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	prefrontal reward consumption MPFC MOFC sucrose Medicine R Science Q Biology (General) QH301-705.5 Linda M Amarante Mark Laubach Coherent theta activity in the medial and orbital frontal cortices encodes reward value
description	This study examined how the medial frontal (MFC) and orbital frontal (OFC) cortices process reward information. We simultaneously recorded local field potentials in the two areas as rats consumed liquid sucrose rewards. Both areas exhibited a 4–8 Hz ‘theta’ rhythm that was phase-locked to the lick cycle. The rhythm tracked shifts in sucrose concentrations and fluid volumes, demonstrating that it is sensitive to differences in reward magnitude. The coupling between the rhythm and licking was stronger in MFC than OFC and varied with response vigor and absolute reward value in the MFC. Spectral analysis revealed zero-lag coherence between the cortical areas, and found evidence for a directionality of the rhythm, with MFC leading OFC. Our findings suggest that consummatory behavior generates simultaneous theta range activity in the MFC and OFC that encodes the value of consumed fluids, with the MFC having a top-down role in the control of consumption.
format	article
author	Linda M Amarante Mark Laubach
author_facet	Linda M Amarante Mark Laubach
author_sort	Linda M Amarante
title	Coherent theta activity in the medial and orbital frontal cortices encodes reward value
title_short	Coherent theta activity in the medial and orbital frontal cortices encodes reward value
title_full	Coherent theta activity in the medial and orbital frontal cortices encodes reward value
title_fullStr	Coherent theta activity in the medial and orbital frontal cortices encodes reward value
title_full_unstemmed	Coherent theta activity in the medial and orbital frontal cortices encodes reward value
title_sort	coherent theta activity in the medial and orbital frontal cortices encodes reward value
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/1b404aaefd2a43c0bd523405ca735b74
work_keys_str_mv	AT lindamamarante coherentthetaactivityinthemedialandorbitalfrontalcorticesencodesrewardvalue AT marklaubach coherentthetaactivityinthemedialandorbitalfrontalcorticesencodesrewardvalue
_version_	1718415034701316096

Coherent theta activity in the medial and orbital frontal cortices encodes reward value

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