REGULATORY T–CELLS: ORIGIN AND FUNCTION
Abstract. Over the past decade a population of so–called “regulatory T cells” (Treg cells) has been linked to the prevention of autoimmunity. In this review we discuss the molecular mechanisms of Treg cells development and function including the identification of the unique molecular marker of Treg...
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SPb RAACI
2014
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oai:doaj.org-article:1b42c9ba70574fdba43de4bf312d8bc02021-11-18T08:03:42ZREGULATORY T–CELLS: ORIGIN AND FUNCTION1563-06252313-741X10.15789/1563-0625-2005-4-347-354https://doaj.org/article/1b42c9ba70574fdba43de4bf312d8bc02014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/467https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Over the past decade a population of so–called “regulatory T cells” (Treg cells) has been linked to the prevention of autoimmunity. In this review we discuss the molecular mechanisms of Treg cells development and function including the identification of the unique molecular marker of Treg cells – the transcription factor Foxp3. We discuss also the mechanisms of suppression, which include the direct cell contact through binding of cell surface molecules CTLA–4 on Treg cells to CD80/CD86 molecules of effector T cells and the local secretion of cytokines (IL–10, TGFβ). Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. These cells are a good target for designing ways to induce or abrogate immunological tolerance to self and non–self antigens. (Med. Immunol., 2005, vol.7, № 4, pp. 347–354)I. S. FreidlinSPb RAACIarticleregulatory t cellsimmunosuppressionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 7, Iss 4, Pp 347-354 (2014) |
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DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
regulatory t cells immunosuppression Immunologic diseases. Allergy RC581-607 |
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regulatory t cells immunosuppression Immunologic diseases. Allergy RC581-607 I. S. Freidlin REGULATORY T–CELLS: ORIGIN AND FUNCTION |
| description |
Abstract. Over the past decade a population of so–called “regulatory T cells” (Treg cells) has been linked to the prevention of autoimmunity. In this review we discuss the molecular mechanisms of Treg cells development and function including the identification of the unique molecular marker of Treg cells – the transcription factor Foxp3. We discuss also the mechanisms of suppression, which include the direct cell contact through binding of cell surface molecules CTLA–4 on Treg cells to CD80/CD86 molecules of effector T cells and the local secretion of cytokines (IL–10, TGFβ). Deficiency in or dysfunction of these cells can be a cause of autoimmune disease. These cells are a good target for designing ways to induce or abrogate immunological tolerance to self and non–self antigens. (Med. Immunol., 2005, vol.7, № 4, pp. 347–354) |
| format |
article |
| author |
I. S. Freidlin |
| author_facet |
I. S. Freidlin |
| author_sort |
I. S. Freidlin |
| title |
REGULATORY T–CELLS: ORIGIN AND FUNCTION |
| title_short |
REGULATORY T–CELLS: ORIGIN AND FUNCTION |
| title_full |
REGULATORY T–CELLS: ORIGIN AND FUNCTION |
| title_fullStr |
REGULATORY T–CELLS: ORIGIN AND FUNCTION |
| title_full_unstemmed |
REGULATORY T–CELLS: ORIGIN AND FUNCTION |
| title_sort |
regulatory t–cells: origin and function |
| publisher |
SPb RAACI |
| publishDate |
2014 |
| url |
https://doaj.org/article/1b42c9ba70574fdba43de4bf312d8bc0 |
| work_keys_str_mv |
AT isfreidlin regulatorytcellsoriginandfunction |
| _version_ |
1718422466159706112 |