<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase

<i>Aster glehni</i> F. Schmidt (AG), is a natural product known to have anti-obesity effects, but the mechanism underlying these effects is not well documented. We hypothesized that AG may have inhibitory effects on enzymes related to lipid accumulation. Herein, AG fractions were tested...

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Autores principales:	Hyunbeom Lee, Hyoung Ja Kim, Hyungi Chae, Na Eun Yoon, Byung Hwa Jung
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Aster glehni</i> F. Schmidt di-caffeoylquinic acid fatty acid synthase HMG-CoA reductase LC–MS/MS polyphenols Botany QK1-989
Acceso en línea:	https://doaj.org/article/1b4346e924bd4b559cfd3fe2427c07d6
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spelling	oai:doaj.org-article:1b4346e924bd4b559cfd3fe2427c07d62021-11-25T18:44:48Z<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase10.3390/plants101122872223-7747https://doaj.org/article/1b4346e924bd4b559cfd3fe2427c07d62021-10-01T00:00:00Zhttps://www.mdpi.com/2223-7747/10/11/2287https://doaj.org/toc/2223-7747<i>Aster glehni</i> F. Schmidt (AG), is a natural product known to have anti-obesity effects, but the mechanism underlying these effects is not well documented. We hypothesized that AG may have inhibitory effects on enzymes related to lipid accumulation. Herein, AG fractions were tested against HMG-CoA reductase (HMGR) and fatty acid synthase (FAS), two important enzymes involved in cholesterol and fatty acid synthesis, respectively. We found that dicaffeoylquinic acid (DCQA) methyl esters present in AG are largely responsible for the inhibition of HMGR and FAS. Since free DCQA is a major form present in AG, we demonstrated that a simple methylation of the AG extract could increase the overall inhibitory effects against those enzymes. Through this simple process, we were able to increase the inhibitory effect by 150%. We believe that our processed AG effectively modulates the HMGR and FAS activities, providing promising therapeutic potential for cholesterol- and lipid-lowering effects.Hyunbeom LeeHyoung Ja KimHyungi ChaeNa Eun YoonByung Hwa JungMDPI AGarticle<i>Aster glehni</i> F. Schmidtdi-caffeoylquinic acidfatty acid synthaseHMG-CoA reductaseLC–MS/MSpolyphenolsBotanyQK1-989ENPlants, Vol 10, Iss 2287, p 2287 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Aster glehni</i> F. Schmidt di-caffeoylquinic acid fatty acid synthase HMG-CoA reductase LC–MS/MS polyphenols Botany QK1-989
spellingShingle	<i>Aster glehni</i> F. Schmidt di-caffeoylquinic acid fatty acid synthase HMG-CoA reductase LC–MS/MS polyphenols Botany QK1-989 Hyunbeom Lee Hyoung Ja Kim Hyungi Chae Na Eun Yoon Byung Hwa Jung <i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase
description	<i>Aster glehni</i> F. Schmidt (AG), is a natural product known to have anti-obesity effects, but the mechanism underlying these effects is not well documented. We hypothesized that AG may have inhibitory effects on enzymes related to lipid accumulation. Herein, AG fractions were tested against HMG-CoA reductase (HMGR) and fatty acid synthase (FAS), two important enzymes involved in cholesterol and fatty acid synthesis, respectively. We found that dicaffeoylquinic acid (DCQA) methyl esters present in AG are largely responsible for the inhibition of HMGR and FAS. Since free DCQA is a major form present in AG, we demonstrated that a simple methylation of the AG extract could increase the overall inhibitory effects against those enzymes. Through this simple process, we were able to increase the inhibitory effect by 150%. We believe that our processed AG effectively modulates the HMGR and FAS activities, providing promising therapeutic potential for cholesterol- and lipid-lowering effects.
format	article
author	Hyunbeom Lee Hyoung Ja Kim Hyungi Chae Na Eun Yoon Byung Hwa Jung
author_facet	Hyunbeom Lee Hyoung Ja Kim Hyungi Chae Na Eun Yoon Byung Hwa Jung
author_sort	Hyunbeom Lee
title	<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase
title_short	<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase
title_full	<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase
title_fullStr	<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase
title_full_unstemmed	<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase
title_sort	<i>aster glehni</i> f. schmidt extract modulates the activities of hmg-coa reductase and fatty acid synthase
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1b4346e924bd4b559cfd3fe2427c07d6
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<i>Aster glehni</i> F. Schmidt Extract Modulates the Activities of HMG-CoA Reductase and Fatty Acid Synthase

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