Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan

Periodontitis is the most prevalent chronic inflammatory oral disease that is characterized by tooth loss and is commonly associated with several systemic inflammatory diseases. Some epidemiological studies suggest that those suffering from periodontitis might be at a greater risk of developing gast...

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Autores principales:	Xin Li, Hitesh Singh Chaouhan, Ching-Hao Li, Tung-Min Yu, I-Kuan Wang, Cheng-Li Lin, Chi-Yuan Li, Kuo-Ting Sun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	periodontitis <i>Helicobacter pylori</i> gastric infection risk factors cohort study Medicine R
Acceso en línea:	https://doaj.org/article/1b4432bb25e646429e84572ff27c4e78
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spelling	oai:doaj.org-article:1b4432bb25e646429e84572ff27c4e782021-11-11T16:46:07ZHigher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan10.3390/ijerph1821116781660-46011661-7827https://doaj.org/article/1b4432bb25e646429e84572ff27c4e782021-11-01T00:00:00Zhttps://www.mdpi.com/1660-4601/18/21/11678https://doaj.org/toc/1661-7827https://doaj.org/toc/1660-4601Periodontitis is the most prevalent chronic inflammatory oral disease that is characterized by tooth loss and is commonly associated with several systemic inflammatory diseases. Some epidemiological studies suggest that those suffering from periodontitis might be at a greater risk of developing gastric <i>Helicobacter pylori</i> (<i>Hp</i>) infection; however, evidence that showing the association between periodontitis and the risk of gastric <i>Hp</i> infection is less clear. We conducted a large-scale, population-based study in Taiwan with a 13-year follow-up period to evaluate the risk of gastric <i>Hp</i> in a periodontitis patient cohort. To conduct this study, we used epidemiological data from the Taiwanese Longitudinal National Health Insurance Research Database (NHIRD) from 2000 to 2013. We selected 134,474 participants (64,868 males and 69,606 females with a minimum age of 20 years), with and without periodontitis, and matched patient cohort groups for age, sex, index year, and co-morbidities. The Cox proportional hazards regression model was used to examine the risk of gastric <i>Hp</i> infection in patients with periodontitis. Patients with periodontitis exhibited a higher risk of developing gastric <i>Hp</i> infection compared to those individuals/groups without periodontitis (1.35 vs. 0.87 per 1000 person-years, adjusted the hazards ratio (aHR 1.52), and 95% confidence intervals (CIs) 1.38–1.67, <i>p</i> < 0.001). The risk of gastric <i>Hp</i> infection persisted even after stratifying by age (aHR = 1.96 (1.79–2.13) for 50–64 years and 1.70 (1.49–1.94) for ≥65 years), gender (aHR = 1.20 (1.11–1.29) for men), and presence of comorbidities of hypertension (aHR = 1.24 (1.11–1.38)), hyperlipidemia (aHR = 1.28 (1.14–1.42)), COPD (aHR = 1.45 (1.31–1.61)), CLD (aHR = 1.62 (1.47–1.77)) and CKD (aHR = 1.44 (1.04–1.99)). Overall, our findings showed that periodontitis patients have a greater risk for gastric <i>Hp</i> than individuals without periodontitis. Clinicians should perform regular good oral hygiene practices, along with newer treatments, for patients with periodontitis, especially those at higher risk of gastric <i>Hp</i> infection.Xin LiHitesh Singh ChaouhanChing-Hao LiTung-Min YuI-Kuan WangCheng-Li LinChi-Yuan LiKuo-Ting SunMDPI AGarticleperiodontitis<i>Helicobacter pylori</i>gastric infectionrisk factorscohort studyMedicineRENInternational Journal of Environmental Research and Public Health, Vol 18, Iss 11678, p 11678 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	periodontitis <i>Helicobacter pylori</i> gastric infection risk factors cohort study Medicine R
spellingShingle	periodontitis <i>Helicobacter pylori</i> gastric infection risk factors cohort study Medicine R Xin Li Hitesh Singh Chaouhan Ching-Hao Li Tung-Min Yu I-Kuan Wang Cheng-Li Lin Chi-Yuan Li Kuo-Ting Sun Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan
description	Periodontitis is the most prevalent chronic inflammatory oral disease that is characterized by tooth loss and is commonly associated with several systemic inflammatory diseases. Some epidemiological studies suggest that those suffering from periodontitis might be at a greater risk of developing gastric <i>Helicobacter pylori</i> (<i>Hp</i>) infection; however, evidence that showing the association between periodontitis and the risk of gastric <i>Hp</i> infection is less clear. We conducted a large-scale, population-based study in Taiwan with a 13-year follow-up period to evaluate the risk of gastric <i>Hp</i> in a periodontitis patient cohort. To conduct this study, we used epidemiological data from the Taiwanese Longitudinal National Health Insurance Research Database (NHIRD) from 2000 to 2013. We selected 134,474 participants (64,868 males and 69,606 females with a minimum age of 20 years), with and without periodontitis, and matched patient cohort groups for age, sex, index year, and co-morbidities. The Cox proportional hazards regression model was used to examine the risk of gastric <i>Hp</i> infection in patients with periodontitis. Patients with periodontitis exhibited a higher risk of developing gastric <i>Hp</i> infection compared to those individuals/groups without periodontitis (1.35 vs. 0.87 per 1000 person-years, adjusted the hazards ratio (aHR 1.52), and 95% confidence intervals (CIs) 1.38–1.67, <i>p</i> < 0.001). The risk of gastric <i>Hp</i> infection persisted even after stratifying by age (aHR = 1.96 (1.79–2.13) for 50–64 years and 1.70 (1.49–1.94) for ≥65 years), gender (aHR = 1.20 (1.11–1.29) for men), and presence of comorbidities of hypertension (aHR = 1.24 (1.11–1.38)), hyperlipidemia (aHR = 1.28 (1.14–1.42)), COPD (aHR = 1.45 (1.31–1.61)), CLD (aHR = 1.62 (1.47–1.77)) and CKD (aHR = 1.44 (1.04–1.99)). Overall, our findings showed that periodontitis patients have a greater risk for gastric <i>Hp</i> than individuals without periodontitis. Clinicians should perform regular good oral hygiene practices, along with newer treatments, for patients with periodontitis, especially those at higher risk of gastric <i>Hp</i> infection.
format	article
author	Xin Li Hitesh Singh Chaouhan Ching-Hao Li Tung-Min Yu I-Kuan Wang Cheng-Li Lin Chi-Yuan Li Kuo-Ting Sun
author_facet	Xin Li Hitesh Singh Chaouhan Ching-Hao Li Tung-Min Yu I-Kuan Wang Cheng-Li Lin Chi-Yuan Li Kuo-Ting Sun
author_sort	Xin Li
title	Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan
title_short	Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan
title_full	Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan
title_fullStr	Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan
title_full_unstemmed	Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan
title_sort	higher risk of gastric <i>helicobacter pylori</i> infection in patients with periodontitis: a nationwide population-based retrospective cohort study in taiwan
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1b4432bb25e646429e84572ff27c4e78
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Higher Risk of Gastric <i>Helicobacter pylori</i> Infection in Patients with Periodontitis: A Nationwide Population-Based Retrospective Cohort Study in Taiwan

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