The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level

Diabetes mellitus is a common metabolic disease marked by hyperglycemia. Diabetes also can be caused by oxidative stress. The administration of antioxidants, whether it’s from food or supplement can inhibit the formation of free radicals. Clinacanthus nutans is reported to possess various medicinal...

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Autores principales:	Ebta Narasukma, Intan Martha Cahyani, Christiana Retnaningsih, Victoria Kristina Ananingsih, Masitoh Suryaning Prahasiwi, Bekti Nugraheni, Afri Diyah Nur Indah Sari
Formato:	article
Lenguaje:	EN
Publicado:	Universitas Gadjah Mada 2021
Materias:	clinacanthus nutans (burm.f) diabetes mellitus high-fat feed fructose Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1b471d45bcfc4f029ab179a0818f0c87
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spelling	oai:doaj.org-article:1b471d45bcfc4f029ab179a0818f0c872021-11-15T06:08:47ZThe Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level2338-94272338-948610.22146/ijp.1230https://doaj.org/article/1b471d45bcfc4f029ab179a0818f0c872021-01-01T00:00:00Zhttps://jurnal.ugm.ac.id/v3/IJP/article/view/1230https://doaj.org/toc/2338-9427https://doaj.org/toc/2338-9486Diabetes mellitus is a common metabolic disease marked by hyperglycemia. Diabetes also can be caused by oxidative stress. The administration of antioxidants, whether it’s from food or supplement can inhibit the formation of free radicals. Clinacanthus nutans is reported to possess various medicinal properties including blood glucose lowering effect, alpha-glucosidase inhibition activity, antioxidant activities, anti-cancer properties and anti-inflammatory effects. Based on research Clinacanthus nutans leaf extracts fractions has several shortcomings, amongst them are its viscosity that gave difficulties in formulation and its astringent and bitter taste that made it hard to use orally. To overcome these shortcomings, microencapsulation can be used. The purpose of this research is to find the blood glucose level lowering effect of the aqueous fraction of microcapsules and to find the effective dose on fructose and fat-induced Wistar strain rat. The induction using fructose and high-fat feed for 55 days was applied. Rats were divided into 8 groups: normal control (aquadest), negative control (Arabic gum and maltodextrin), positive control (metformin), dose I 15,89 mg/ kgBW (microcapsule of aqueous fraction of Clinacanthus nutans extract), dose II 31,78 mg/ kgBW, dose III 47,67 mg/ kgBW, dose IV 63.56 mg /kgBW, and dose V 79.45 mg/ kgBW. The result showed that the microcapsules of the aqueous fraction of Clinacanthus nutans (Burm.f) extract could lower Wistar strain rat blood glucose level in the dose of 15.89 mg/kg of the rat’s body weight.Ebta NarasukmaIntan Martha CahyaniChristiana RetnaningsihVictoria Kristina AnaningsihMasitoh Suryaning PrahasiwiBekti NugraheniAfri Diyah Nur Indah SariUniversitas Gadjah Madaarticleclinacanthus nutans (burm.f)diabetes mellitushigh-fat feedfructosePharmacy and materia medicaRS1-441ENIndonesian Journal of Pharmacy, Pp 126-131 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	clinacanthus nutans (burm.f) diabetes mellitus high-fat feed fructose Pharmacy and materia medica RS1-441
spellingShingle	clinacanthus nutans (burm.f) diabetes mellitus high-fat feed fructose Pharmacy and materia medica RS1-441 Ebta Narasukma Intan Martha Cahyani Christiana Retnaningsih Victoria Kristina Ananingsih Masitoh Suryaning Prahasiwi Bekti Nugraheni Afri Diyah Nur Indah Sari The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level
description	Diabetes mellitus is a common metabolic disease marked by hyperglycemia. Diabetes also can be caused by oxidative stress. The administration of antioxidants, whether it’s from food or supplement can inhibit the formation of free radicals. Clinacanthus nutans is reported to possess various medicinal properties including blood glucose lowering effect, alpha-glucosidase inhibition activity, antioxidant activities, anti-cancer properties and anti-inflammatory effects. Based on research Clinacanthus nutans leaf extracts fractions has several shortcomings, amongst them are its viscosity that gave difficulties in formulation and its astringent and bitter taste that made it hard to use orally. To overcome these shortcomings, microencapsulation can be used. The purpose of this research is to find the blood glucose level lowering effect of the aqueous fraction of microcapsules and to find the effective dose on fructose and fat-induced Wistar strain rat. The induction using fructose and high-fat feed for 55 days was applied. Rats were divided into 8 groups: normal control (aquadest), negative control (Arabic gum and maltodextrin), positive control (metformin), dose I 15,89 mg/ kgBW (microcapsule of aqueous fraction of Clinacanthus nutans extract), dose II 31,78 mg/ kgBW, dose III 47,67 mg/ kgBW, dose IV 63.56 mg /kgBW, and dose V 79.45 mg/ kgBW. The result showed that the microcapsules of the aqueous fraction of Clinacanthus nutans (Burm.f) extract could lower Wistar strain rat blood glucose level in the dose of 15.89 mg/kg of the rat’s body weight.
format	article
author	Ebta Narasukma Intan Martha Cahyani Christiana Retnaningsih Victoria Kristina Ananingsih Masitoh Suryaning Prahasiwi Bekti Nugraheni Afri Diyah Nur Indah Sari
author_facet	Ebta Narasukma Intan Martha Cahyani Christiana Retnaningsih Victoria Kristina Ananingsih Masitoh Suryaning Prahasiwi Bekti Nugraheni Afri Diyah Nur Indah Sari
author_sort	Ebta Narasukma
title	The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level
title_short	The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level
title_full	The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level
title_fullStr	The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level
title_full_unstemmed	The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level
title_sort	effect of aqueous fraction of clinacanthusnutans (burm.f.) extract microcapsules on rat blood glucose level
publisher	Universitas Gadjah Mada
publishDate	2021
url	https://doaj.org/article/1b471d45bcfc4f029ab179a0818f0c87
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The Effect of Aqueous Fraction of Clinacanthusnutans (Burm.F.) Extract Microcapsules on Rat Blood Glucose Level

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