Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.

Viral infections have been implicated in the pathogenesis of multiple sclerosis. Epstein-Barr virus (EBV) has frequently been investigated as a possible candidate and torque teno virus (TTV) has also been discussed in this context. Nevertheless, mechanistic aspects remain unresolved. We report viral...

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Autores principales:	Silvia S Borkosky, Corinna Whitley, Annette Kopp-Schneider, Harald zur Hausen, Ethel-Michele de Villiers
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b4a21df2001498e8961657ef3affe22
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spelling	oai:doaj.org-article:1b4a21df2001498e8961657ef3affe222021-11-18T07:27:01ZEpstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.1932-620310.1371/journal.pone.0032160https://doaj.org/article/1b4a21df2001498e8961657ef3affe222012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22384166/?tool=EBIhttps://doaj.org/toc/1932-6203Viral infections have been implicated in the pathogenesis of multiple sclerosis. Epstein-Barr virus (EBV) has frequently been investigated as a possible candidate and torque teno virus (TTV) has also been discussed in this context. Nevertheless, mechanistic aspects remain unresolved. We report viral replication, as measured by genome amplification, as well as quantitative PCR of two TTV-HD14 isolates isolated from multiple sclerosis brain in a series of EBV-positive and -negative lymphoblastoid and Burkitt's lymphoma cell lines. Our results demonstrate the replication of both transfected TTV genomes up to day 21 post transfection in all the evaluated cell lines. Quantitative amplification indicates statistically significant enhanced TTV replication in the EBV-positive cell lines, including the EBV-converted BJAB line, in comparison to the EBV-negative Burkitt's lymphoma cell line BJAB. This suggests a helper effect of EBV infections in the replication of TTV. The present study provides information on a possible interaction of EBV and TTV in the etiology and progression of multiple sclerosis.Silvia S BorkoskyCorinna WhitleyAnnette Kopp-SchneiderHarald zur HausenEthel-Michele de VilliersPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e32160 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Silvia S Borkosky Corinna Whitley Annette Kopp-Schneider Harald zur Hausen Ethel-Michele de Villiers Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.
description	Viral infections have been implicated in the pathogenesis of multiple sclerosis. Epstein-Barr virus (EBV) has frequently been investigated as a possible candidate and torque teno virus (TTV) has also been discussed in this context. Nevertheless, mechanistic aspects remain unresolved. We report viral replication, as measured by genome amplification, as well as quantitative PCR of two TTV-HD14 isolates isolated from multiple sclerosis brain in a series of EBV-positive and -negative lymphoblastoid and Burkitt's lymphoma cell lines. Our results demonstrate the replication of both transfected TTV genomes up to day 21 post transfection in all the evaluated cell lines. Quantitative amplification indicates statistically significant enhanced TTV replication in the EBV-positive cell lines, including the EBV-converted BJAB line, in comparison to the EBV-negative Burkitt's lymphoma cell line BJAB. This suggests a helper effect of EBV infections in the replication of TTV. The present study provides information on a possible interaction of EBV and TTV in the etiology and progression of multiple sclerosis.
format	article
author	Silvia S Borkosky Corinna Whitley Annette Kopp-Schneider Harald zur Hausen Ethel-Michele de Villiers
author_facet	Silvia S Borkosky Corinna Whitley Annette Kopp-Schneider Harald zur Hausen Ethel-Michele de Villiers
author_sort	Silvia S Borkosky
title	Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.
title_short	Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.
title_full	Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.
title_fullStr	Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.
title_full_unstemmed	Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.
title_sort	epstein-barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/1b4a21df2001498e8961657ef3affe22
work_keys_str_mv	AT silviasborkosky epsteinbarrvirusstimulatestorquetenovirusreplicationapossiblerelationshiptomultiplesclerosis AT corinnawhitley epsteinbarrvirusstimulatestorquetenovirusreplicationapossiblerelationshiptomultiplesclerosis AT annettekoppschneider epsteinbarrvirusstimulatestorquetenovirusreplicationapossiblerelationshiptomultiplesclerosis AT haraldzurhausen epsteinbarrvirusstimulatestorquetenovirusreplicationapossiblerelationshiptomultiplesclerosis AT ethelmicheledevilliers epsteinbarrvirusstimulatestorquetenovirusreplicationapossiblerelationshiptomultiplesclerosis
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Epstein-Barr virus stimulates torque teno virus replication: a possible relationship to multiple sclerosis.

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