Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis

Syphilitic hepatitis (SH) in adults is a rare condition that can be easily misdiagnosed. Clinical and histopathologic manifestations of SH can mimic other infectious and non-infectious conditions, and the diagnosis should be considered in all at-risk patients with abnormal liver function tests. We p...

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Autores principales:	Hiba A. Al Dallal, Siddharth Narayanan, Hanah F. Alley, Michael J. Eiswerth, Forest W. Arnold, Brock A. Martin, Alaleh E. Shandiz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	syphilis drug abuse hepatitis seizure liver enzymes infection Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1b51ff2862e3467ca95400f9fe021c50
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spelling	oai:doaj.org-article:1b51ff2862e3467ca95400f9fe021c502021-12-01T13:16:05ZCase Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis2296-858X10.3389/fmed.2021.789250https://doaj.org/article/1b51ff2862e3467ca95400f9fe021c502021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.789250/fullhttps://doaj.org/toc/2296-858XSyphilitic hepatitis (SH) in adults is a rare condition that can be easily misdiagnosed. Clinical and histopathologic manifestations of SH can mimic other infectious and non-infectious conditions, and the diagnosis should be considered in all at-risk patients with abnormal liver function tests. We present an unusual case of SH presenting with seizures and multiple liver lesions. This case report, in line with other newly published reports, promotes awareness of SH as a rare manifestation of treponemal infection and highlights the importance of including SH in the differential diagnosis for patients at risk for sexually transmitted infections and presenting with liver enzyme abnormalities. From a hospital quality control and socioeconomic perspective, our case adds to the growing body of evidence that demonstrates an increasing incidence of patients suffering from venereal diseases and injection drug use disorders, and the burden these conditions place on the healthcare system. Recognition of the clinicopathologic features of SH is required to prevent missed diagnosis and to foster systematic crosstalk between healthcare staff and public health personnel managing this problem.Hiba A. Al DallalSiddharth NarayananHanah F. AlleyMichael J. EiswerthForest W. ArnoldBrock A. MartinAlaleh E. ShandizFrontiers Media S.A.articlesyphilisdrug abusehepatitisseizureliver enzymesinfectionMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	syphilis drug abuse hepatitis seizure liver enzymes infection Medicine (General) R5-920
spellingShingle	syphilis drug abuse hepatitis seizure liver enzymes infection Medicine (General) R5-920 Hiba A. Al Dallal Siddharth Narayanan Hanah F. Alley Michael J. Eiswerth Forest W. Arnold Brock A. Martin Alaleh E. Shandiz Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis
description	Syphilitic hepatitis (SH) in adults is a rare condition that can be easily misdiagnosed. Clinical and histopathologic manifestations of SH can mimic other infectious and non-infectious conditions, and the diagnosis should be considered in all at-risk patients with abnormal liver function tests. We present an unusual case of SH presenting with seizures and multiple liver lesions. This case report, in line with other newly published reports, promotes awareness of SH as a rare manifestation of treponemal infection and highlights the importance of including SH in the differential diagnosis for patients at risk for sexually transmitted infections and presenting with liver enzyme abnormalities. From a hospital quality control and socioeconomic perspective, our case adds to the growing body of evidence that demonstrates an increasing incidence of patients suffering from venereal diseases and injection drug use disorders, and the burden these conditions place on the healthcare system. Recognition of the clinicopathologic features of SH is required to prevent missed diagnosis and to foster systematic crosstalk between healthcare staff and public health personnel managing this problem.
format	article
author	Hiba A. Al Dallal Siddharth Narayanan Hanah F. Alley Michael J. Eiswerth Forest W. Arnold Brock A. Martin Alaleh E. Shandiz
author_facet	Hiba A. Al Dallal Siddharth Narayanan Hanah F. Alley Michael J. Eiswerth Forest W. Arnold Brock A. Martin Alaleh E. Shandiz
author_sort	Hiba A. Al Dallal
title	Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis
title_short	Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis
title_full	Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis
title_fullStr	Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis
title_full_unstemmed	Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis
title_sort	case report: syphilitic hepatitis–a rare and underrecognized etiology of liver disease with potential for misdiagnosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/1b51ff2862e3467ca95400f9fe021c50
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Case Report: Syphilitic Hepatitis–A Rare and Underrecognized Etiology of Liver Disease With Potential for Misdiagnosis

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