Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation

Background: Currently, one of the main problems that happens in the treatment by extracorporeal methods of hemosorption is systemic shifts in homeostasis. Among these complications the most significant are blood cells traumatization and hemorrhage. Direct physical contact of blood with sorbent surfa...

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Autor principal:	Andrey N. Belousov
Formato:	article
Lenguaje:	EN
Publicado:	Emergency Department of Hospital San Pedro (Logroño, Spain) 2019
Materias:	platelets functional mcs-b nanoparticles saline solution aggregation rate aggregation index Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/1b58d5b5642147f9953c68daf021ee5c
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spelling	oai:doaj.org-article:1b58d5b5642147f9953c68daf021ee5c2021-12-02T15:37:03ZInvestigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation10.5281/zenodo.35932882695-5075https://doaj.org/article/1b58d5b5642147f9953c68daf021ee5c2019-12-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3593288https://doaj.org/toc/2695-5075Background: Currently, one of the main problems that happens in the treatment by extracorporeal methods of hemosorption is systemic shifts in homeostasis. Among these complications the most significant are blood cells traumatization and hemorrhage. Direct physical contact of blood with sorbent surface causes activation of a multistage reaction of thrombosis. Now, new methods of hemosorption using non-traumatic sorbents are being actively developed. Wide introduction of nanotechnological preparations (magnetite nanoparticles) in clinical medicine allows improving methods of hemocorrection, creating a new class magnetically sorbent. The aim of this study is to know the activity of magnet-controlled sorbent inhibiting the aggregation of platelets in an in vitro model. Materials and Methods: 0.9% NaCl, magnetite nanoparticles of magnet-controlled sorbent (MCS-B brand). Object of research: platelets in relatively healthy volunteers. Quantitative determination aggregation of platelets activity by using aggregometer A-1 was carried out by the Bornov's method in the modification of Zachary and Kinah. Results and discussions: The results of the study showed that the use of NaCl saline solution shifts the colloidal suspension equilibrium of platelets towards a significant (P<0.001) increase in the rate and index of their aggregation. For the first time, the effect of 0.9% NaCl on function of platelets makes us reconsider the concept of safety of infusion solutions in patients with initial signs of platelet disorders hemostasis. On the contrary, the use of MCS-B nanoparticles significantly revealed (P<0.05) an increase in the stability of colloidal suspension of platelets. This is an important pathogenetic factor which affects the occurrence of correction of hemostasis in conditions of blood clotting disorders.Andrey N. BelousovEmergency Department of Hospital San Pedro (Logroño, Spain)articleplateletsfunctionalmcs-b nanoparticlessaline solutionaggregation rateaggregation indexMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 1, Pp 24-29 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelets functional mcs-b nanoparticles saline solution aggregation rate aggregation index Medicine (General) R5-920
spellingShingle	platelets functional mcs-b nanoparticles saline solution aggregation rate aggregation index Medicine (General) R5-920 Andrey N. Belousov Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation
description	Background: Currently, one of the main problems that happens in the treatment by extracorporeal methods of hemosorption is systemic shifts in homeostasis. Among these complications the most significant are blood cells traumatization and hemorrhage. Direct physical contact of blood with sorbent surface causes activation of a multistage reaction of thrombosis. Now, new methods of hemosorption using non-traumatic sorbents are being actively developed. Wide introduction of nanotechnological preparations (magnetite nanoparticles) in clinical medicine allows improving methods of hemocorrection, creating a new class magnetically sorbent. The aim of this study is to know the activity of magnet-controlled sorbent inhibiting the aggregation of platelets in an in vitro model. Materials and Methods: 0.9% NaCl, magnetite nanoparticles of magnet-controlled sorbent (MCS-B brand). Object of research: platelets in relatively healthy volunteers. Quantitative determination aggregation of platelets activity by using aggregometer A-1 was carried out by the Bornov's method in the modification of Zachary and Kinah. Results and discussions: The results of the study showed that the use of NaCl saline solution shifts the colloidal suspension equilibrium of platelets towards a significant (P<0.001) increase in the rate and index of their aggregation. For the first time, the effect of 0.9% NaCl on function of platelets makes us reconsider the concept of safety of infusion solutions in patients with initial signs of platelet disorders hemostasis. On the contrary, the use of MCS-B nanoparticles significantly revealed (P<0.05) an increase in the stability of colloidal suspension of platelets. This is an important pathogenetic factor which affects the occurrence of correction of hemostasis in conditions of blood clotting disorders.
format	article
author	Andrey N. Belousov
author_facet	Andrey N. Belousov
author_sort	Andrey N. Belousov
title	Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation
title_short	Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation
title_full	Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation
title_fullStr	Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation
title_full_unstemmed	Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation
title_sort	investigation of the effect of magnetite nanoparticles (mcs-b) on human platelet aggregation
publisher	Emergency Department of Hospital San Pedro (Logroño, Spain)
publishDate	2019
url	https://doaj.org/article/1b58d5b5642147f9953c68daf021ee5c
work_keys_str_mv	AT andreynbelousov investigationoftheeffectofmagnetitenanoparticlesmcsbonhumanplateletaggregation
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Investigation of the Effect of Magnetite Nanoparticles (MCS-B) on Human Platelet Aggregation

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