Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.

<h4>Background</h4>Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current repo...

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Autores principales:	Anastase Dzudie, Donald Hoover, Hae-Young Kim, Rogers Ajeh, Adebola Adedimeji, Qiuhu Shi, Walter Pefura Yone, Denis Nsame Nforniwe, Kinge Thompson Njie, Andre Pascal Kengne, Peter Vanes Ebasone, Blaise Barche, Zoung-Kany Bissek Anne Cecile, Denis Nash, Marcel Yotebieng, Kathryn Anastos
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b59d799853e4a3cb4d733f1484be886
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spelling	oai:doaj.org-article:1b59d799853e4a3cb4d733f1484be8862021-12-02T20:06:40ZHypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.1932-620310.1371/journal.pone.0253742https://doaj.org/article/1b59d799853e4a3cb4d733f1484be8862021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0253742https://doaj.org/toc/1932-6203<h4>Background</h4>Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current report describes the prevalence and predictors of HTN among PLWH in care in Cameroon.<h4>Methods</h4>This cross-sectional study included all PLWH aged 20 years and above who received care between 2016 and 2019 at one of the three Central Africa International Epidemiology Databases to Evaluate AIDS (CA-IeDEA) sites in Cameroon (Bamenda, Limbe, and Yaoundé). HTN was defined as blood pressure (BP) ≥140/90 mm Hg or self-reported use of antihypertensive medication. Logistic regressions models examined the relationship between HTN and clinical characteristics, and HIV-related factors.<h4>Results</h4>Among 9,839 eligible PLWH, 66.2% were women and 25.0% had prevalent HTN [age-standardized prevalence 23.9% (95% CI: 22.2-25.6)], among whom 28 (1.1%) were on BP lowering treatment, and 6 of those (21.4%) were at target BP levels. Median age (47.4 vs. 40.5 years), self-reported duration of HIV infection (5.1 vs 2.8 years years), duration of ART exposure (4.7 vs 2.3 years), and CD4 count (408 vs 359 cell/mm3) were higher in hypertensives than non-hypertensives (all p<0.001). Age and body mass index (BMI) were independently associated with higher prevalent HTN risk. PLWH starting ART had a 30% lower risk of prevalent HTN, but this advantage disappeared after a cumulative 2-year exposure to ART. There was no significant association between other HIV predictive characteristics and HTN.<h4>Conclusion</h4>About a quarter of these Cameroonian PLWH had HTN, driven among others by age and adiposity. Appropriate integration of HIV and NCDs services is needed to improve early detection, treatment and control of common comorbid NCD risk factors like hypertension and safeguard cardiovascular health in PLWH.Anastase DzudieDonald HooverHae-Young KimRogers AjehAdebola AdedimejiQiuhu ShiWalter Pefura YoneDenis Nsame NforniweKinge Thompson NjieAndre Pascal KengnePeter Vanes EbasoneBlaise BarcheZoung-Kany Bissek Anne CecileDenis NashMarcel YotebiengKathryn AnastosPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0253742 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anastase Dzudie Donald Hoover Hae-Young Kim Rogers Ajeh Adebola Adedimeji Qiuhu Shi Walter Pefura Yone Denis Nsame Nforniwe Kinge Thompson Njie Andre Pascal Kengne Peter Vanes Ebasone Blaise Barche Zoung-Kany Bissek Anne Cecile Denis Nash Marcel Yotebieng Kathryn Anastos Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.
description	<h4>Background</h4>Antiretroviral therapy (ART) success has led people to live longer with HIV/AIDS (PLWH) and thus be exposed to increasing risk of cardiovascular diseases (CVD). Hypertension (HTN), the biggest contributor to CVD burden, is a growing concern among PLWH. The current report describes the prevalence and predictors of HTN among PLWH in care in Cameroon.<h4>Methods</h4>This cross-sectional study included all PLWH aged 20 years and above who received care between 2016 and 2019 at one of the three Central Africa International Epidemiology Databases to Evaluate AIDS (CA-IeDEA) sites in Cameroon (Bamenda, Limbe, and Yaoundé). HTN was defined as blood pressure (BP) ≥140/90 mm Hg or self-reported use of antihypertensive medication. Logistic regressions models examined the relationship between HTN and clinical characteristics, and HIV-related factors.<h4>Results</h4>Among 9,839 eligible PLWH, 66.2% were women and 25.0% had prevalent HTN [age-standardized prevalence 23.9% (95% CI: 22.2-25.6)], among whom 28 (1.1%) were on BP lowering treatment, and 6 of those (21.4%) were at target BP levels. Median age (47.4 vs. 40.5 years), self-reported duration of HIV infection (5.1 vs 2.8 years years), duration of ART exposure (4.7 vs 2.3 years), and CD4 count (408 vs 359 cell/mm3) were higher in hypertensives than non-hypertensives (all p<0.001). Age and body mass index (BMI) were independently associated with higher prevalent HTN risk. PLWH starting ART had a 30% lower risk of prevalent HTN, but this advantage disappeared after a cumulative 2-year exposure to ART. There was no significant association between other HIV predictive characteristics and HTN.<h4>Conclusion</h4>About a quarter of these Cameroonian PLWH had HTN, driven among others by age and adiposity. Appropriate integration of HIV and NCDs services is needed to improve early detection, treatment and control of common comorbid NCD risk factors like hypertension and safeguard cardiovascular health in PLWH.
format	article
author	Anastase Dzudie Donald Hoover Hae-Young Kim Rogers Ajeh Adebola Adedimeji Qiuhu Shi Walter Pefura Yone Denis Nsame Nforniwe Kinge Thompson Njie Andre Pascal Kengne Peter Vanes Ebasone Blaise Barche Zoung-Kany Bissek Anne Cecile Denis Nash Marcel Yotebieng Kathryn Anastos
author_facet	Anastase Dzudie Donald Hoover Hae-Young Kim Rogers Ajeh Adebola Adedimeji Qiuhu Shi Walter Pefura Yone Denis Nsame Nforniwe Kinge Thompson Njie Andre Pascal Kengne Peter Vanes Ebasone Blaise Barche Zoung-Kany Bissek Anne Cecile Denis Nash Marcel Yotebieng Kathryn Anastos
author_sort	Anastase Dzudie
title	Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.
title_short	Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.
title_full	Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.
title_fullStr	Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.
title_full_unstemmed	Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.
title_sort	hypertension among people living with hiv/aids in cameroon: a cross-sectional analysis from central africa international epidemiology databases to evaluate aids.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/1b59d799853e4a3cb4d733f1484be886
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Hypertension among people living with HIV/AIDS in Cameroon: A cross-sectional analysis from Central Africa International Epidemiology Databases to Evaluate AIDS.

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