Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by inhibitors of purine synthesis.

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Autores principales:	Weihua Zhou, Yangyang Yao, Andrew J. Scott, Kari Wilder-Romans, Joseph J. Dresser, Christian K. Werner, Hanshi Sun, Drew Pratt, Peter Sajjakulnukit, Shuang G. Zhao, Mary Davis, Barbara S. Nelson, Christopher J. Halbrook, Li Zhang, Francesco Gatto, Yoshie Umemura, Angela K. Walker, Maureen Kachman, Jann N. Sarkaria, Jianping Xiong, Meredith A. Morgan, Alnawaz Rehemtualla, Maria G. Castro, Pedro Lowenstein, Sriram Chandrasekaran, Theodore S. Lawrence, Costas A. Lyssiotis, Daniel R. Wahl
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1b59daa1bcd04cf3a9e4d552dbc954ba
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spelling	oai:doaj.org-article:1b59daa1bcd04cf3a9e4d552dbc954ba2021-12-02T18:46:58ZPurine metabolism regulates DNA repair and therapy resistance in glioblastoma10.1038/s41467-020-17512-x2041-1723https://doaj.org/article/1b59daa1bcd04cf3a9e4d552dbc954ba2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17512-xhttps://doaj.org/toc/2041-1723Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by inhibitors of purine synthesis.Weihua ZhouYangyang YaoAndrew J. ScottKari Wilder-RomansJoseph J. DresserChristian K. WernerHanshi SunDrew PrattPeter SajjakulnukitShuang G. ZhaoMary DavisBarbara S. NelsonChristopher J. HalbrookLi ZhangFrancesco GattoYoshie UmemuraAngela K. WalkerMaureen KachmanJann N. SarkariaJianping XiongMeredith A. MorganAlnawaz RehemtuallaMaria G. CastroPedro LowensteinSriram ChandrasekaranTheodore S. LawrenceCostas A. LyssiotisDaniel R. WahlNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Weihua Zhou Yangyang Yao Andrew J. Scott Kari Wilder-Romans Joseph J. Dresser Christian K. Werner Hanshi Sun Drew Pratt Peter Sajjakulnukit Shuang G. Zhao Mary Davis Barbara S. Nelson Christopher J. Halbrook Li Zhang Francesco Gatto Yoshie Umemura Angela K. Walker Maureen Kachman Jann N. Sarkaria Jianping Xiong Meredith A. Morgan Alnawaz Rehemtualla Maria G. Castro Pedro Lowenstein Sriram Chandrasekaran Theodore S. Lawrence Costas A. Lyssiotis Daniel R. Wahl Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
description	Targeting genotype-independent abnormalities may overcome therapy resistance in glioblastoma despite intratumoral genomic heterogeneity. Here, the authors show that glioblastoma radiation resistance is promoted by purine metabolism and can be overcome by inhibitors of purine synthesis.
format	article
author	Weihua Zhou Yangyang Yao Andrew J. Scott Kari Wilder-Romans Joseph J. Dresser Christian K. Werner Hanshi Sun Drew Pratt Peter Sajjakulnukit Shuang G. Zhao Mary Davis Barbara S. Nelson Christopher J. Halbrook Li Zhang Francesco Gatto Yoshie Umemura Angela K. Walker Maureen Kachman Jann N. Sarkaria Jianping Xiong Meredith A. Morgan Alnawaz Rehemtualla Maria G. Castro Pedro Lowenstein Sriram Chandrasekaran Theodore S. Lawrence Costas A. Lyssiotis Daniel R. Wahl
author_facet	Weihua Zhou Yangyang Yao Andrew J. Scott Kari Wilder-Romans Joseph J. Dresser Christian K. Werner Hanshi Sun Drew Pratt Peter Sajjakulnukit Shuang G. Zhao Mary Davis Barbara S. Nelson Christopher J. Halbrook Li Zhang Francesco Gatto Yoshie Umemura Angela K. Walker Maureen Kachman Jann N. Sarkaria Jianping Xiong Meredith A. Morgan Alnawaz Rehemtualla Maria G. Castro Pedro Lowenstein Sriram Chandrasekaran Theodore S. Lawrence Costas A. Lyssiotis Daniel R. Wahl
author_sort	Weihua Zhou
title	Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
title_short	Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
title_full	Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
title_fullStr	Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
title_full_unstemmed	Purine metabolism regulates DNA repair and therapy resistance in glioblastoma
title_sort	purine metabolism regulates dna repair and therapy resistance in glioblastoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/1b59daa1bcd04cf3a9e4d552dbc954ba
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Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

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