Ocular surface squamous neoplasia in HIV-infected patients: current perspectives

Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India Abstract: Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcino...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rathi SG, Ganguly Kapoor A, Kaliki S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Eye Conjunctiva OSSN Ocular surface squamous neoplasia HIV Human immunodeficiency virus Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/1b5b98196b7b472183b7ea53aafb0f2b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1b5b98196b7b472183b7ea53aafb0f2b
record_format	dspace
spelling	oai:doaj.org-article:1b5b98196b7b472183b7ea53aafb0f2b2021-12-02T04:49:42ZOcular surface squamous neoplasia in HIV-infected patients: current perspectives1179-1373https://doaj.org/article/1b5b98196b7b472183b7ea53aafb0f2b2018-03-01T00:00:00Zhttps://www.dovepress.com/ocular-surface-squamous-neoplasia-in-hiv-infected-patients-current-per-peer-reviewed-article-HIVhttps://doaj.org/toc/1179-1373Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India Abstract: Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure. OSSN has been reported as the first presenting sign of HIV/AIDS in 26%–86% cases, and seropositivity is noted in 38%–92% OSSN patients. Mean age at presentation of OSSN has dropped to the third to fourth decade in HIV-positive patients in developing countries. HIV-infected patients reveal large aggressive tumors, higher-grade malignancy, higher incidence of corneal, scleral, and orbital invasion, advanced-stage T4 tumors, higher need for extended enucleation/exenteration, and increased risk of tumor recurrence. Current management of OSSN in HIV-positive individuals is based on standard treatment guidelines described for OSSN in the general population, as there is little information available about various treatment modalities or their outcomes in patients with HIV. OSSN can occur at any time in the disease course of HIV/AIDS, and no significant trend has been discovered between CD4 count and grade of OSSN. Furthermore, the effect of highly active antiretroviral therapy on OSSN is controversial. The current recommendation is to conduct HIV screening in all cases presenting with OSSN to rule out undiagnosed HIV infection. Patient counseling is crucial, with emphasis on regular follow-up to address high recurrence rates and early presentation to an ophthalmologist for of any symptoms in the unaffected eye. Effective evidence-based interventions are needed to allow early diagnosis and treatment, as well as prevention of the disease. Keywords: eye, conjunctiva, OSSN, ocular surface squamous neoplasia, HIV, human immunodeficiency virusRathi SGGanguly Kapoor AKaliki SDove Medical PressarticleEyeConjunctivaOSSNOcular surface squamous neoplasiaHIVHuman immunodeficiency virusImmunologic diseases. AllergyRC581-607ENHIV/AIDS: Research and Palliative Care, Vol Volume 10, Pp 33-45 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Eye Conjunctiva OSSN Ocular surface squamous neoplasia HIV Human immunodeficiency virus Immunologic diseases. Allergy RC581-607
spellingShingle	Eye Conjunctiva OSSN Ocular surface squamous neoplasia HIV Human immunodeficiency virus Immunologic diseases. Allergy RC581-607 Rathi SG Ganguly Kapoor A Kaliki S Ocular surface squamous neoplasia in HIV-infected patients: current perspectives
description	Shweta Gupta Rathi, Anasua Ganguly Kapoor, Swathi Kaliki Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India Abstract: Ocular surface squamous neoplasia (OSSN) refers to a spectrum of conjunctival and corneal epithelial tumors including dysplasia, carcinoma in situ, and invasive carcinoma. In this article, we discuss the current perspectives of OSSN associated with HIV infection, focusing mainly on the epidemiology, pathophysiology, clinical manifestations, diagnosis, and treatment of these tumors in patients with HIV. Upsurge in the incidence of OSSN with the HIV pandemic most severely affected sub-Saharan Africa, due to associated risk factors, such as human papilloma virus and solar ultraviolet exposure. OSSN has been reported as the first presenting sign of HIV/AIDS in 26%–86% cases, and seropositivity is noted in 38%–92% OSSN patients. Mean age at presentation of OSSN has dropped to the third to fourth decade in HIV-positive patients in developing countries. HIV-infected patients reveal large aggressive tumors, higher-grade malignancy, higher incidence of corneal, scleral, and orbital invasion, advanced-stage T4 tumors, higher need for extended enucleation/exenteration, and increased risk of tumor recurrence. Current management of OSSN in HIV-positive individuals is based on standard treatment guidelines described for OSSN in the general population, as there is little information available about various treatment modalities or their outcomes in patients with HIV. OSSN can occur at any time in the disease course of HIV/AIDS, and no significant trend has been discovered between CD4 count and grade of OSSN. Furthermore, the effect of highly active antiretroviral therapy on OSSN is controversial. The current recommendation is to conduct HIV screening in all cases presenting with OSSN to rule out undiagnosed HIV infection. Patient counseling is crucial, with emphasis on regular follow-up to address high recurrence rates and early presentation to an ophthalmologist for of any symptoms in the unaffected eye. Effective evidence-based interventions are needed to allow early diagnosis and treatment, as well as prevention of the disease. Keywords: eye, conjunctiva, OSSN, ocular surface squamous neoplasia, HIV, human immunodeficiency virus
format	article
author	Rathi SG Ganguly Kapoor A Kaliki S
author_facet	Rathi SG Ganguly Kapoor A Kaliki S
author_sort	Rathi SG
title	Ocular surface squamous neoplasia in HIV-infected patients: current perspectives
title_short	Ocular surface squamous neoplasia in HIV-infected patients: current perspectives
title_full	Ocular surface squamous neoplasia in HIV-infected patients: current perspectives
title_fullStr	Ocular surface squamous neoplasia in HIV-infected patients: current perspectives
title_full_unstemmed	Ocular surface squamous neoplasia in HIV-infected patients: current perspectives
title_sort	ocular surface squamous neoplasia in hiv-infected patients: current perspectives
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1b5b98196b7b472183b7ea53aafb0f2b
work_keys_str_mv	AT rathisg ocularsurfacesquamousneoplasiainhivinfectedpatientscurrentperspectives AT gangulykapoora ocularsurfacesquamousneoplasiainhivinfectedpatientscurrentperspectives AT kalikis ocularsurfacesquamousneoplasiainhivinfectedpatientscurrentperspectives
_version_	1718400994037989376

Ocular surface squamous neoplasia in HIV-infected patients: current perspectives

Ejemplares similares