Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011

Abstract The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. We evaluated the association of the TyG index with low muscle mass using a nationwide population-based representative data. This is a cross-sectional study that included 9477 participants aged ≥ 40 year...

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Autores principales:	Jung A. Kim, Soon Young Hwang, Ji Hee Yu, Eun Roh, So-hyeon Hong, You-Bin Lee, Nam Hoon Kim, Hye Jin Yoo, Ji A. Seo, Nan Hee Kim, Sin Gon Kim, Sei Hyun Baik, Kyung Mook Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1b5c02bc4f8d450fa8a1b3b97504d4d9
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spelling	oai:doaj.org-article:1b5c02bc4f8d450fa8a1b3b97504d4d92021-12-02T15:22:59ZAssociation of the triglyceride and glucose index with low muscle mass: KNHANES 2008–201110.1038/s41598-020-80305-12045-2322https://doaj.org/article/1b5c02bc4f8d450fa8a1b3b97504d4d92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80305-1https://doaj.org/toc/2045-2322Abstract The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. We evaluated the association of the TyG index with low muscle mass using a nationwide population-based representative data. This is a cross-sectional study that included 9477 participants aged ≥ 40 years from the Korea National Health and Nutrition Examination Survey between 2008 and 2011. The TyG index was calculated as ln[triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Dual-energy X-ray absorptiometry was used to measure appendicular lean mass (ALM). Low muscle mass was defined an ALM/weight of 2 standard deviations (SD) below of young participants. The overall prevalence of low muscle mass was 4.7%. The prevalence of low muscle mass increased linearly with the quartiles of the TyG index, 2.5%, 4.2%, 5.6%, and 6.7% in Q1–Q4, respectively. The TyG index was negatively associated with ALM/weight both in men (r = − 0.302) and women (r = − 0.230). The odds ratio (OR) for low muscle mass was 2.08 in the highest quartile compared to the lowest quartile. High TyG index was associated with an increased risk of low muscle mass (OR for 1SD increase: 1.13). Increased TyG index was associated with the risk of low muscle mass independent of confounding factors.Jung A. KimSoon Young HwangJi Hee YuEun RohSo-hyeon HongYou-Bin LeeNam Hoon KimHye Jin YooJi A. SeoNan Hee KimSin Gon KimSei Hyun BaikKyung Mook ChoiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jung A. Kim Soon Young Hwang Ji Hee Yu Eun Roh So-hyeon Hong You-Bin Lee Nam Hoon Kim Hye Jin Yoo Ji A. Seo Nan Hee Kim Sin Gon Kim Sei Hyun Baik Kyung Mook Choi Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
description	Abstract The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. We evaluated the association of the TyG index with low muscle mass using a nationwide population-based representative data. This is a cross-sectional study that included 9477 participants aged ≥ 40 years from the Korea National Health and Nutrition Examination Survey between 2008 and 2011. The TyG index was calculated as ln[triglyceride (mg/dL) × fasting plasma glucose (mg/dL)/2]. Dual-energy X-ray absorptiometry was used to measure appendicular lean mass (ALM). Low muscle mass was defined an ALM/weight of 2 standard deviations (SD) below of young participants. The overall prevalence of low muscle mass was 4.7%. The prevalence of low muscle mass increased linearly with the quartiles of the TyG index, 2.5%, 4.2%, 5.6%, and 6.7% in Q1–Q4, respectively. The TyG index was negatively associated with ALM/weight both in men (r = − 0.302) and women (r = − 0.230). The odds ratio (OR) for low muscle mass was 2.08 in the highest quartile compared to the lowest quartile. High TyG index was associated with an increased risk of low muscle mass (OR for 1SD increase: 1.13). Increased TyG index was associated with the risk of low muscle mass independent of confounding factors.
format	article
author	Jung A. Kim Soon Young Hwang Ji Hee Yu Eun Roh So-hyeon Hong You-Bin Lee Nam Hoon Kim Hye Jin Yoo Ji A. Seo Nan Hee Kim Sin Gon Kim Sei Hyun Baik Kyung Mook Choi
author_facet	Jung A. Kim Soon Young Hwang Ji Hee Yu Eun Roh So-hyeon Hong You-Bin Lee Nam Hoon Kim Hye Jin Yoo Ji A. Seo Nan Hee Kim Sin Gon Kim Sei Hyun Baik Kyung Mook Choi
author_sort	Jung A. Kim
title	Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
title_short	Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
title_full	Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
title_fullStr	Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
title_full_unstemmed	Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011
title_sort	association of the triglyceride and glucose index with low muscle mass: knhanes 2008–2011
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1b5c02bc4f8d450fa8a1b3b97504d4d9
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Association of the triglyceride and glucose index with low muscle mass: KNHANES 2008–2011

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