The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

Zhang et al. present the cryo-electron microscopy structures of the two neuronal cation-chloride cotransporters human NKCC1 and mouse KCC2, identifying their essential residues for ion transport. This study proposes mechanisms by which phosphorylation regulates the activity of these cation-chloride...

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Autores principales: Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel, Wei Zhuo, Suma Somasekharan, Kasturi Roy, Laixing Zhang, Yang Liu, Xianbin Meng, Haiteng Deng, Wenwen Zeng, Guohui Li, Biff Forbush, Maojun Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Biology (General)
QH301-705.5
Acceso en línea:https://doaj.org/article/1b5dcbea19614a15900e1d27bebbbc65
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spelling oai:doaj.org-article:1b5dcbea19614a15900e1d27bebbbc652021-12-02T14:21:58ZThe structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC210.1038/s42003-021-01750-w2399-3642https://doaj.org/article/1b5dcbea19614a15900e1d27bebbbc652021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01750-whttps://doaj.org/toc/2399-3642Zhang et al. present the cryo-electron microscopy structures of the two neuronal cation-chloride cotransporters human NKCC1 and mouse KCC2, identifying their essential residues for ion transport. This study proposes mechanisms by which phosphorylation regulates the activity of these cation-chloride cotransporters.Sensen ZhangJun ZhouYuebin ZhangTianya LiuPerrine FriedelWei ZhuoSuma SomasekharanKasturi RoyLaixing ZhangYang LiuXianbin MengHaiteng DengWenwen ZengGuohui LiBiff ForbushMaojun YangNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Biology (General)
QH301-705.5
spellingShingle Biology (General)
QH301-705.5
Sensen Zhang
Jun Zhou
Yuebin Zhang
Tianya Liu
Perrine Friedel
Wei Zhuo
Suma Somasekharan
Kasturi Roy
Laixing Zhang
Yang Liu
Xianbin Meng
Haiteng Deng
Wenwen Zeng
Guohui Li
Biff Forbush
Maojun Yang
The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
description Zhang et al. present the cryo-electron microscopy structures of the two neuronal cation-chloride cotransporters human NKCC1 and mouse KCC2, identifying their essential residues for ion transport. This study proposes mechanisms by which phosphorylation regulates the activity of these cation-chloride cotransporters.
format article
author Sensen Zhang
Jun Zhou
Yuebin Zhang
Tianya Liu
Perrine Friedel
Wei Zhuo
Suma Somasekharan
Kasturi Roy
Laixing Zhang
Yang Liu
Xianbin Meng
Haiteng Deng
Wenwen Zeng
Guohui Li
Biff Forbush
Maojun Yang
author_facet Sensen Zhang
Jun Zhou
Yuebin Zhang
Tianya Liu
Perrine Friedel
Wei Zhuo
Suma Somasekharan
Kasturi Roy
Laixing Zhang
Yang Liu
Xianbin Meng
Haiteng Deng
Wenwen Zeng
Guohui Li
Biff Forbush
Maojun Yang
author_sort Sensen Zhang
title The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
title_short The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
title_full The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
title_fullStr The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
title_full_unstemmed The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
title_sort structural basis of function and regulation of neuronal cotransporters nkcc1 and kcc2
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/1b5dcbea19614a15900e1d27bebbbc65
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